GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. - Wikidata - awgldk - TriplyDB

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist.

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist.

http://www.wikidata.org/entity/Q40294227

about

The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Prostanoid receptor antagonists: development strategies and therapeutic applications Lubiprostone targets prostanoid EP₄ receptors in ovine airways.Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein.EP4 receptor stimulation down-regulates human eosinophil function.EP4 receptor as a new target for bronchodilator therapy IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with the involvement of cycloxygenase-2 and prostaglandin E2.Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model.Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon.GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype.Differential effects of prostaglandin E2-sensitive receptors on contractility of human ocular cells that regulate conventional outflow Estradiol-17beta, prostaglandin E2 (PGE2), and the PGE2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium.Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy.Prostaglandin EP4 antagonists.Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines.N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry.Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4.Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal.Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype.Characterization of biosynthesis and modes of action of prostaglandin E2 and prostacyclin in guinea pig mesenteric lymphatic vessels.Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells.Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis.Dynamical modelling of prostaglandin signalling in platelets reveals individual receptor contributions and feedback properties.Characterization of the EP receptor types that mediate longitudinal smooth muscle contraction of human colon, mouse colon and mouse ileum

P2860

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P2860

GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist.

http://www.wikidata.org/entity/Q40294227

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

@zh-tw

2006年论文

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2006年论文

@zh

2006年论文

@zh-cn

name

GW627368X ((N-{2-[4-(4,9-dieth ...... anoid EP4 receptor antagonist.

@en

type

label

GW627368X ((N-{2-[4-(4,9-dieth ...... anoid EP4 receptor antagonist.

@en

prefLabel

GW627368X ((N-{2-[4-(4,9-dieth ...... anoid EP4 receptor antagonist.

@en

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P1433

British Journal of Pharmacology

P1476

GW627368X ((N-{2-[4-(4,9-dieth ...... anoid EP4 receptor antagonist.

@en

P2093

Alan Wise

http://www.w3.org/2001/XMLSchema#string

Cynthia L Burns-Kurtis

http://www.w3.org/2001/XMLSchema#string

David W Gray

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Gerard M P Giblin

http://www.w3.org/2001/XMLSchema#string

Heather Giles

http://www.w3.org/2001/XMLSchema#string

Jannatara Chowdhury

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Jason Brown

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Jim Coote

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Kerri-Ann Cartwright

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Lloyd S Noel

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P2860

Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

Molecular cloning and characterization of the human prostanoid DP receptor

Cloning and expression of three isoforms of the human EP3 prostanoid receptor

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Prostanoid receptor subtypes

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist

Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2

P304

326-339

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scholarly article

P356

10.1038/SJ.BJP.0706726

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P433

3

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P478

148

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2006-06-01T00:00:00Z

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7176028

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16604093

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1751567

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