The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.
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Citrullination: a small change for a protein with great consequences for rheumatoid arthritisRheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentinCitrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodiesThe antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodiesDetection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis seraCitrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severityProteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritisACPAs Are Much More Than Diagnostic AutoantibodiesHornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skinMyelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analysesSecretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis.Attitudes to early rheumatoid arthritis: changing patterns. Results of a survey.Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium.Increased IgA antibodies to cytokeratins in the spondyloarthropathiesBead arrays for antibody and complement profiling reveal joint contribution of antibody isotypes to C3 deposition.Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodiesLowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.Antibodies to citrullinated protein antigens (ACPAs): clinical and pathophysiologic significanceIsolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture.Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis.Anti-citrullinated protein antibodies and their clinical utility in rheumatoid arthritis.Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides.Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis.Pathomechanisms in rheumatoid arthritis--time for a string theory?Autoantibodies in rheumatoid arthritis and their clinical significance.A systematic review of serum biomarkers anti-cyclic citrullinated Peptide and rheumatoid factor as tests for rheumatoid arthritisAnti-perinuclear factor compared with the so called "antikeratin" antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides.Serum samples of patients with rheumatoid arthritis contain a specific autoantibody to "denatured" aldolase A in the osteoblast-like cell line, MG-63Association of autoantibodies to filaggrin with an active disease in early rheumatoid arthritis.Performance of two ELISAs for antifilaggrin autoantibodies, using either affinity purified or deiminated recombinant human filaggrin, in the diagnosis of rheumatoid arthritis.Prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis.A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French populationA new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritisDecreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.Physical Characteristics of a Citrullinated Pro-Filaggrin Epitope Recognized by Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Sera.The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target.Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis associationAutoantibodies to intracellular autoantigens and their B-cell epitopes: molecular probes to study the autoimmune response.Normal human epidermal keratinocytes express in vitro specific molecular forms of (pro)filaggrin recognized by rheumatoid arthritis-associated antifilaggrin autoantibodies.Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies.
P2860
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P2860
The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The cytokeratin filament-aggre ...... ific for rheumatoid arthritis.
@en
type
label
The cytokeratin filament-aggre ...... ific for rheumatoid arthritis.
@en
prefLabel
The cytokeratin filament-aggre ...... ific for rheumatoid arthritis.
@en
P2093
P2860
P356
P1476
The cytokeratin filament-aggre ...... ific for rheumatoid arthritis.
@en
P2093
Gomès-Daudrix V
P2860
P304
P356
10.1172/JCI116713
P407
P577
1993-09-01T00:00:00Z