Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. - Wikidata - awgldk - TriplyDB

Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

http://www.wikidata.org/entity/Q40310128

about

Retroviral intasome assembly and inhibition of DNA strand transfer Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)Computational methods in drug discovery Novel therapeutic strategies targeting HIV integrase Functional and structural characterization of the integrase from the prototype foamy virus Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric Assembly Approved Antiviral Drugs over the Past 50 Years A historical sketch of the discovery and development of HIV-1 integrase inhibitors Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome Unprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravir Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitors Contribution of human immunodeficiency virus type 1 minority variants to reduced drug susceptibility in patients on an integrase strand transfer inhibitor-based therapy Retroviral DNA Integration In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay.Critical appraisal of elvitegravir in the treatment of HIV-1/AIDS.HIV-1 IN inhibitors: 2010 update and perspectives Mechanisms and inhibition of HIV integration Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir Pharmacokinetics and dose-range finding toxicity of a novel anti-HIV active integrase inhibitor.New first and second generation inhibitors of human immunodeficiency virus-1 integrase.Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.Physical trapping of HIV-1 synaptic complex by different structural classes of integrase strand transfer inhibitors.Retroviral Integrase Structure and DNA Recombination Mechanism Novel 3'-Processing Integrase Activity Assay by Real-Time PCR for Screening and Identification of HIV-1 Integrase Inhibitors.A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity.Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors.HIV-1 antiretroviral drug therapy.Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.Computer tools in the discovery of HIV-1 integrase inhibitors Authentic HIV-1 integrase inhibitors.Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors.Tautomerism and magnesium chelation of HIV-1 integrase inhibitors: a theoretical study.One-pot phosphine-catalyzed syntheses of quinolines Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.Raltegravir: molecular basis of its mechanism of action Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro.

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P2860

Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

http://www.wikidata.org/entity/Q40310128

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

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Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

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Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

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Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.

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P2093

Hiroshi Kawakami

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Hisashi Shinkai

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Hisateru Aramaki

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Kazunobu Yamataka

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Masaki Yamashita

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Motohide Sato

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Satoru Ikeda

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Takahisa Motomura

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Takashi Matsuda

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Wataru Watanabe

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1506-1508

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scholarly article

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10.1021/JM0600139

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