A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association.
about
Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatasesAurora A, centrosome structure, and the centrosome cyclePlk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBoraThe centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1Regulation of the centrosome cycleCross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle AssemblyCell division: control of the chromosomal passenger complex in time and spacePlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionLocalized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cellsUse of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitorsIdentification of small molecule inhibitors of the Aurora-A/TPX2 complexSomatic cells regulate maternal mRNA translation and developmental competence of mouse oocytesEvidence toward a dual phosphatase mechanism that restricts Aurora A (Thr-295) phosphorylation during the early embryonic cell cycle.Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytesSpatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidyThe Plk1-dependent phosphoproteome of the early mitotic spindleWNK1 is required for mitosis and abscission.The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regulation of HURP's distribution on microtubules.Centrosome dynamics as a source of chromosomal instabilityThe essential role of evasion from cell death in cancer.Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forcesProteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic processTargeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer TreatmentA highly efficient multifunctional tandem affinity purification approach applicable to diverse organisms.Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.Structural and regulatory roles of nonmotor spindle proteinsInterdependence of cell attachment and cell cycle signaling.Target validation and biomarker identification in oncology : the example of aurora kinases.Modulating polo-like kinase 1 as a means for cancer chemopreventionCell cycle proteins as promising targets in cancer therapyMechanisms of Chromosome Congression during Mitosis.Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.The molecular basis for kinesin functional specificity during mitosis.TPX2: of spindle assembly, DNA damage response, and cancer.Mitotic spindle multipolarity without centrosome amplification.
P2860
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P2860
A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A functional interplay between ...... and TPX2 spindle association.
@en
type
label
A functional interplay between ...... and TPX2 spindle association.
@en
prefLabel
A functional interplay between ...... and TPX2 spindle association.
@en
P356
P1433
P1476
A functional interplay between ...... A and TPX2 spindle association
@en
P2093
Giulia Guarguaglini
Patrizia Lavia
P304
P356
10.4161/CC.5.3.2392
P577
2006-02-07T00:00:00Z