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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic functionBax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosisHow insulin engages its primary binding site on the insulin receptorStructural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonistsA newly discovered protein export machine in malaria parasitesThe structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusionCatalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolaseStructural studies of the resistance of influenza virus neuramindase to inhibitorsStructural Basis for Broad Substrate Specificity in Higher Plant beta-D-Glucan GlucohydrolasesThree-dimensional structure of the barley beta-D-glucan glucohydrolase in complex with a transition state mimicStructural insights into the degradation of Mcl-1 induced by BH3 domainsCrystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 familyHigh-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xLStructural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serineConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsDomain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channelsStructural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignInsights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparumCrystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteinsEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsStabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activityStructure-Guided Rescaffolding of Selective Antagonists of BCL-X LStructure-guided design of a selective BCL-X(L) inhibitorProtective hinge in insulin opens to enable its receptor engagementCrystal structure and immunological properties of the first annexin from Schistosoma mansoni: insights into the structural integrity of the schistosomal tegumentDe-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterizationStructural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytesA minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulinStructure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyaseA malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasionThe D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferationInhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasitesBioPPSy: An Open-Source Platform for QSAR/QSPR AnalysisAnalysis of structure and function of the giant protein Pf332 in Plasmodium falciparumAromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.Modulation of voltage-gated K+ channels by the sodium channel β1 subunitHigher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).
P50
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P50
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Brian J. Smith
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Brian J. Smith
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