RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
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Crystal structure of native RPE65, the retinoid isomerase of the visual cycleRecent advances in the dark adaptation investigationsStructural basis of carotenoid cleavage: from bacteria to mammalsStructure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)Catalytic mechanism of a retinoid isomerase essential for vertebrate visionMembrane-binding and enzymatic properties of RPE65Chemistry of the retinoid (visual) cycleRetinol dehydrogenase 13 protects the mouse retina from acute light damageGenomewide analysis of carotenoid cleavage dioxygenases in unicellular and filamentous cyanobacteriaNegative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.RPE65: role in the visual cycle, human retinal disease, and gene therapy.The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice.The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.The retinal pigment epithelium in health and diseaseIron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms?An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brainInterphotoreceptor retinoid-binding protein (IRBP) promotes retinol uptake and release by rat Müller cells (rMC-1) in vitro: implications for the cone visual cycleEnzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase.Identification of carotenoid cleavage dioxygenases from Nostoc sp. PCC 7120 with different cleavage activities.Key enzymes of the retinoid (visual) cycle in vertebrate retinaMammalian carotenoid-oxygenases: key players for carotenoid function and homeostasisAdipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.Metabolism of carotenoids and retinoids related to vision.Differentiation of Human Protein-Induced Pluripotent Stem Cells toward a Retinal Pigment Epithelial Cell Fate.An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species.Identification of the key residues determining the product specificity of isomerohydrolase.Utilization of Dioxygen by Carotenoid Cleavage Oxygenases.Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanismRPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species.Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agentsAltered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitf(mi) and Mitf(vitiligo) mouse mutants.Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65.Iron metabolism in the eye: a review.A comprehensive clinical and biochemical functional study of a novel RPE65 hypomorphic mutationIron homeostasis and eye disease.The cone-specific visual cycle.Retinyl ester hydrolases and their roles in vitamin A homeostasis.The Status of RPE65 Gene Therapy Trials: Safety and EfficacySynthesis of laboratory Ultrasound Contrast Agents.
P2860
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P2860
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
@en
type
label
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
@en
prefLabel
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
@en
P2093
P2860
P356
P1476
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle
@en
P2093
Gennadiy Moiseyev
Jian-Xing Ma
Rosalie K Crouch
S Gentleman
Yusuke Takahashi
P2860
P304
P356
10.1074/JBC.M508903200
P407
P577
2005-11-30T00:00:00Z