Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency.
about
Effects of template sequence and secondary structure on DNA-templated reactivityComputational biology of RNA interactionsRab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channelsNuclear receptor nhr-48 is required for pathogenicity of the second stage (J2) of the plant parasite Meloidogyne incognita.Improved knockdown from artificial microRNAs in an enhanced miR-155 backbone: a designer's guide to potent multi-target RNAiIn silico target-specific siRNA design based on domain transfer in heterogeneous data.Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features.Forward and robust selection of the most potent and noncellular toxic siRNAs from RNAi libraries.A structural interpretation of the effect of GC-content on efficiency of RNA interference.Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library.Predicting siRNA potency with random forests and support vector machinesOligonucleotide-based strategies to combat polyglutamine diseases.Quantitative prediction of miRNA-mRNA interaction based on equilibrium concentrations.Improved siRNA/shRNA functionality by mismatched duplex.Nucleic acid sequence design via efficient ensemble defect optimization.Principles for Predicting RNA Secondary Structure Design DifficultySiRNA sequence model: redesign algorithm based on available genome-wide libraries.Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments.Whole-genome thermodynamic analysis reduces siRNA off-target effects.RNAi therapeutics: principles, prospects and challenges.Designing highly active siRNAs for therapeutic applications.Alternative splicing as a therapeutic target for human diseases.RNA interference screening for the discovery of oncology targets.MysiRNA-designer: a workflow for efficient siRNA design.More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signatureEffect of target secondary structure on RNAi efficiency.Efficient production of superior dumbbell-shaped DNA minimal vectors for small hairpin RNA expression.On future's doorstep: RNA interference and the pharmacopeia of tomorrow.Optimized models for design of efficient miR30-based shRNAs.siRNA efficiency: structure or sequence-that is the question.Nucleic acid therapeutics for hematologic malignancies--theoretical considerations.Opportunities for treating chronic hepatitis B and C virus infection using RNA interference.Design of siRNA Therapeutics from the Molecular ScaleImpact of target mRNA structure on siRNA silencing efficiency: A large-scale studyA universal TaqMan-based RT-PCR protocol for cost-efficient detection of small noncoding RNA.In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.Action and reaction: the biological response to siRNA and its delivery vehicles.Therapeutic siRNA: principles, challenges, and strategies.Selection of hyperfunctional siRNAs with improved potency and specificityApproximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency.
P2860
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P2860
Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Design of siRNAs producing uns ...... d RNA interference efficiency.
@en
type
label
Design of siRNAs producing uns ...... d RNA interference efficiency.
@en
prefLabel
Design of siRNAs producing uns ...... d RNA interference efficiency.
@en
P2093
P2860
P50
P356
P1433
P1476
Design of siRNAs producing uns ...... ed RNA interference efficiency
@en
P2093
Christian Köberle
Isabell Dietrich
Sascha Rutz
P2860
P2888
P304
P356
10.1038/NBT1151
P577
2005-10-30T00:00:00Z