Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. - Wikidata - awgldk - TriplyDB

Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth.

Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth.

http://www.wikidata.org/entity/Q40358363

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Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells Glucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6 Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo.Mig-6 controls EGFR trafficking and suppresses gliomagenesis Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum Disorders (ASDs).Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.Decreased Mitogen Inducible Gene 6 (MIG-6) Associated with Symptom Severity in Children with Autism.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.Differential RNA Expression Profile of Skeletal Muscle Induced by Experimental Autoimmune Myasthenia Gravis in Rats.EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF.New insights into the control of neurotrophic growth factor receptor signaling: implications for nervous system development and repair.Nuclear Gene 33/Mig6 Regulates the DNA Damage Response through an ATM-dependent Mechanism.Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6 Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling.Establishment of an immortalized porcine liver cell line JSNK-1 with retroviral transduction of SV40T.Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma.Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours.A pervasive role for MIG6 in restraining cell proliferation.Hepatocyte growth factor and the hepatocyte growth factor receptor signalling complex as targets in cancer therapies Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas.Feedback regulation of RTK signaling in development.Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation.Expression and regulation of the differentiation regulators ERBB Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon-related Developmental Regulator 1 (IFRD1) during the periovulatory period in the rat ovary.Mig-6 Mouse Model of Endometrial Cancer.Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.

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Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth.

http://www.wikidata.org/entity/Q40358363

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2005 nî lūn-bûn

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Mitogen-inducible gene 6 is an ...... migration and neurite growth.

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Alun M Davies

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Fabienne Lamballe

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Flavio Maina

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Guido Pante

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Ingvar Ferby

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Jane Thompson

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Rüdiger Klein

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Tomoko Iwata

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P2860

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stre

Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype.

Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Feedback inhibition by RALT controls signal output by the ErbB network

Mig-6 is a negative regulator of the epidermal growth factor receptor signal

Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control

Met, metastasis, motility and more

Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin

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337-348

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10.1083/JCB.200502013

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2

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171

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Francis A. Barr

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2005-10-01T00:00:00Z

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28324771

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16247031

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2171179

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