Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
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Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channelsKCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemiaMechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channelsAcute alterations of somatodendritic action potential dynamics in hippocampal CA1 pyramidal cells after kainate-induced status epilepticus in miceThe riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channelsUnstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activationFunctional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channelPharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memorySustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold.Calcium-dependent control of temporal processing in an auditory interneuron: a computational analysisThe small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum.Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureMolecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.CA1 hippocampal network activity changes during sleep-dependent memory consolidationIntrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice.Intermediate-conductance calcium-activated potassium channels participate in neurovascular coupling.Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic ratsFunctional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons.Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses.RyR2 modulates a Ca2+-activated K+ current in mouse cardiac myocytes.Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin InterfaceSelective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complexIn vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain modelSympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus.Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons.Increasing SK2 channel activity impairs associative learningSelective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membraneBlockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory.Intrinsic and Network Mechanisms Constrain Neural Synchrony in the Moth Antennal Lobe.Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neuronsAssociation of Small-Conductance Calcium-Activated Potassium Channels and Atrial Fibrillation - How Far Have We Gone?Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's diseaseK+ channel modulators for the treatment of neurological disorders and autoimmune diseasesThe therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseasesRestoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neuronsIonic and neuromodulatory regulation of burst discharge controls frequency tuning.
P2860
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P2860
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Specific enhancement of SK cha ...... hippocampal pyramidal neurons.
@en
type
label
Specific enhancement of SK cha ...... hippocampal pyramidal neurons.
@en
prefLabel
Specific enhancement of SK cha ...... hippocampal pyramidal neurons.
@en
P2093
P356
P1476
Specific enhancement of SK cha ...... hippocampal pyramidal neurons
@en
P2093
Bo Skaaning Jensen
Charlotte Hougaard
Dorte Strøbaek
Gregor Rogge
Martin Stocker
Palle Christophersen
Paola Pedarzani
P304
41404-41411
P356
10.1074/JBC.M509610200
P407
P577
2005-10-20T00:00:00Z