Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses.
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Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applicationsNanoparticles as potential new generation broad spectrum antimicrobial agentsSPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humansA phase I randomized placebo controlled trial of the safety of 3% SPL7013 Gel (VivaGel®) in healthy young women administered twice daily for 14 daysStructure activity relationship of dendrimer microbicides with dual action antiviral activityClinical Translation of Nanomedicine.Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants.Microbicides and other topical agents in the prevention of HIV and sexually transmitted infections.Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groupsEvaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis.Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate modelVirucidal activity of the dendrimer microbicide SPL7013 against HIV-1.Soluble Immune Mediators and Vaginal Bacteria Impact Innate Genital Mucosal Antimicrobial Activity in Young Women.Dendrimers functionalized with membrane-interacting peptides for viral inhibition.Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract.Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: mechanism of antiviral action.Exploiting herpes simplex virus entry for novel therapeutics.A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.VivaGel (SPL7013 Gel): a candidate dendrimer--microbicide for the prevention of HIV and HSV infectionA randomized controlled trial of the safety of candidate microbicide SPL7013 gel when applied to the penis.Novel approaches in fighting herpes simplex virus infectionsFormulating a sulfonated antiviral dendrimer in a vaginal microbicidal gel having dual mechanisms of actionDendrimers--revolutionary drugs for infectious diseases.Peptide inhibitors against herpes simplex virus infections.Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections.Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers.Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid.GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses.Inhibition of HSV-1 attachment, entry, and cell-to-cell spread by functionalized multivalent gold nanoparticles.Antiviral activity of Bifidobacterium adolescentis SPM 0214 against herpes simplex virus type 1.Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfateDendrimers as topical microbicides with activity against HIVUnexpected Biological Applications of Dendrimers and Specific Multivalency Activities
P2860
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P2860
Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Evaluation of dendrimer SPL701 ...... gainst herpes simplex viruses.
@en
type
label
Evaluation of dendrimer SPL701 ...... gainst herpes simplex viruses.
@en
prefLabel
Evaluation of dendrimer SPL701 ...... gainst herpes simplex viruses.
@en
P2093
P1433
P1476
Evaluation of dendrimer SPL701 ...... gainst herpes simplex viruses.
@en
P2093
Barry Matthews
Edwin Gong
George Holan
Jianhua Chu
Stephen Sacks
Tom McCarthy
P304
P356
10.1016/J.ANTIVIRAL.2005.08.004
P577
2005-09-27T00:00:00Z