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Conus venom peptide pharmacologyδ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snailsSolution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channelsIsolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequenceOmega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminalsAChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivityCrystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides insights into the mechanism of substrate recognitionIsolation and characterization of peptides from Momordica cochinchinensis seedsChemical synthesis and structure of the prokineticin Bv8Conopeptide -TIA Defines a New Allosteric Site on the Extracellular Surface of the 1B-AdrenoceptorEfficient chemical synthesis of human complement protein C3aChemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venomIdentification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriensA consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopyTherapeutic potential of venom peptidesThe alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channelsBrevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cellsEscherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs)Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional BioassayAnalysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West IndiesRole of voltage-gated calcium channels in ascending pain pathwaysThe structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusAEvolution of separate predation- and defence-evoked venoms in carnivorous cone snailsPharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry.Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel.High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked painThe tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.Use of venom peptides to probe ion channel structure and function.Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.Ciguatera fish poisoning in the Pacific Islands (1998 to 2008).Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex.Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily.Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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ريتشارد جيه. لويس
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type
label
Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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ريتشارد جيه. لويس
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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Richard J. Lewis
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ريتشارد جيه. لويس
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P1053
E-8674-2013
P106
P1153
55457251800
P21
P31
P3829
P496
0000-0003-3470-923X