Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Item
http://www.wikidata.org/entity/Q40373664
X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitorsThe p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.Tandem mass spectrometry study of p38α kinase inhibitors and related substances.A new strategy for the synthesis of β-benzylmercaptoethylamine derivativesMacrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinaseTNFalpha blockade in human diseases: mechanisms and future directions.Discontinued drugs in 2006: pulmonary-allergy, dermatological, gastrointestinal and arthritis drugs.Targeting signaling pathways with small molecules to treat autoimmune disorders.p38α mitogen-activated protein kinase inhibitors, a patent review (2005-2011).Solvent-free and catalysts-free chemistry: a benign pathway to sustainability.Development of anti-angiogenic tyrosine kinases inhibitors: molecular structures and binding modes.Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents.Synthetic phosphorylation of p38α recapitulates protein kinase activitytert-Butyl N-benzyl-N-[4-(4-fluoro-benzoyl-meth-yl)-2-pyrid-yl]carbamatetert-Butyl N-benzyl-N-(4-methyl-2-pyrid-yl)carbamate.Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS.Thiazole formation through a modified Gewald reaction.
P2860

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Item
http://www.wikidata.org/entity/Q40373664
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Novel inhibitor of p38 MAP kin ...... ti-rheumatoid arthritis agent.
@en
type
label
Novel inhibitor of p38 MAP kin ...... ti-rheumatoid arthritis agent.
@en
prefLabel
Novel inhibitor of p38 MAP kin ...... ti-rheumatoid arthritis agent.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Novel inhibitor of p38 MAP kin ...... ti-rheumatoid arthritis agent.
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921