Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.
about
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteNkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic isletTargeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genesMODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cellsDefining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning.MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells.Regulation of pancreas duodenum homeobox-1 expression by early growth response-1.The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell Development.Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice.
P2860
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P2860
Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Interactions between areas I a ...... ature and developing pancreas.
@en
type
label
Interactions between areas I a ...... ature and developing pancreas.
@en
prefLabel
Interactions between areas I a ...... ature and developing pancreas.
@en
P2093
P2860
P356
P1476
Interactions between areas I a ...... ature and developing pancreas.
@en
P2093
Isabella Artner
Jennifer C Van Velkinburgh
Kevin Gerrish
Roland Stein
Susan E Samaras
P2860
P304
38438-38444
P356
10.1074/JBC.M508594200
P407
P577
2005-09-07T00:00:00Z