The folding trajectory of RNase H is dominated by its topology and not local stability: a protein engineering study of variants that fold via two-state and three-state mechanisms.
about
Protein high-force pulling simulations yield low-force results.Take home lessons from studies of related proteinsEvolutionary trend toward kinetic stability in the folding trajectory of RNases H.The H2A-H2B dimeric kinetic intermediate is stabilized by widespread hydrophobic burial with few fully native interactions.Probing the Folding-Unfolding Transition of a Thermophilic Protein, MTH1880Early folding events protect aggregation-prone regions of a β-rich protein.Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry.The folding of single domain proteins--have we reached a consensus?Topological and sequence information predict that foldons organize a partially overlapped and hierarchical structure.Non-native structure appears in microseconds during the folding of E. coli RNase H.Evidence of a folding intermediate in RNase H from single-molecule FRET experiments.Packing energetics determine the folding routes of the RNase-H proteins.Kinetic and structural comparison of a protein's cotranslational folding and refolding pathways.Tracing a protein's folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange
P2860
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P2860
The folding trajectory of RNase H is dominated by its topology and not local stability: a protein engineering study of variants that fold via two-state and three-state mechanisms.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-my
2009年学术文章
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2009年學術文章
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name
The folding trajectory of RNas ...... te and three-state mechanisms.
@en
type
label
The folding trajectory of RNas ...... te and three-state mechanisms.
@en
prefLabel
The folding trajectory of RNas ...... te and three-state mechanisms.
@en
P2093
P2860
P1476
The folding trajectory of RNas ...... te and three-state mechanisms.
@en
P2093
Erik J Miller
Katelyn B Connell
Susan Marqusee
P2860
P304
P356
10.1016/J.JMB.2009.05.085
P407
P577
2009-06-06T00:00:00Z