DNA damage and mutagenesis induced by nitrogen mustards.
about
Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepairSpecificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequenceMechanisms of resistance to alkylating agentsCellular response to DNA interstrand crosslinks: the Fanconi anemia pathwayGenotoxicants target distinct molecular networks in neonatal neuronsAn inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cellsModulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cellsExpression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamideDNA repair modulates the vulnerability of the developing brain to alkylating agentsReplication and repair of a reduced 2΄-deoxyguanosine-abasic site interstrand cross-link in human cells.Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidatesA rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cellsToward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcriptionC. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiencyMechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells.Thiol-activated DNA damage by α-bromo-2-cyclopentenone.Characterization of nitrogen mustard formamidopyrimidine adduct formation of bis(2-chloroethyl)ethylamine with calf thymus DNA and a human mammary cancer cell lineAnnealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1.A comprehensive survey of the mutagenic impact of common cancer cytotoxicsFanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy.Influence of DNA damage and repair upon the risk of treatment related leukemia.An evaluation of the mode of action framework for mutagenic carcinogens case study: Cyclophosphamide.Simple, High-Yield Syntheses of DNA Duplexes Containing Interstrand DNA-DNA Cross-Links Between an N(4) -Aminocytidine Residue and an Abasic SiteChemotherapy-induced bladder cancer.Effects of the aldehyde dehydrogenase inhibitor disulfiram on the plasma pharmacokinetics, metabolism, and toxicity of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice.Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic ApproachDNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.Immunostimulatory Effects of Melphalan and Usefulness in Adoptive Cell Therapy with Antitumor CD4+ T Cells.DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine.DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias.Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approachEvaluation of chemical mutagenicity using next generation sequencing: A review.Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?Mass Spectrometry-Based Tools to Characterize DNA-Protein Cross-Linking by Bis-Electrophiles.Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells.Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae.Thermoresponsive chlorambucil derivatives for tumour targeting.Protein-DNA interactions in the human beta-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards.
P2860
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P2860
DNA damage and mutagenesis induced by nitrogen mustards.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
DNA damage and mutagenesis induced by nitrogen mustards.
@en
type
label
DNA damage and mutagenesis induced by nitrogen mustards.
@en
prefLabel
DNA damage and mutagenesis induced by nitrogen mustards.
@en
P1433
P1476
DNA damage and mutagenesis induced by nitrogen mustards.
@en
P2093
P304
P356
10.1016/0165-1110(94)90015-9
P407
P577
1994-12-01T00:00:00Z