Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.
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Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationRadiotherapy and "new" drugs-new side effects?Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesisA novel classification of lung cancer into molecular subtypesEpidermal growth factor receptor inhibitors for radiotherapy: biological rationale and preclinical results.Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEKK-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia.Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT.Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation.Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation.Predicting response to epidermal growth factor receptor-targeted therapy in colorectal cancer.MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands.Cell adhesion-mediated radioresistance revisited.Radiation-induced EGFR-signaling and control of DNA-damage repair.Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: a reviewDual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.Current concepts in clinical radiation oncology.Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors.Nuclear EGFR as novel therapeutic target: insights into nuclear translocation and function.Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents.The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development.EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer.Identification of AREG and PLK1 pathway modulation as a potential key of the response of intracranial 9L tumor to microbeam radiation therapy.Connecting cancer biology and clinical outcomes to imaging in KRAS mutant and wild-type colorectal cancer liver tumors following selective internal radiation therapy with yttrium-90.FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells.Expression of Smac induced by the Egr1 promoter enhances the radiosensitivity of breast cancer cells.Targeting the AKT/cyclin D1 pathway to overcome intrinsic and acquired radioresistance of tumors for effective radiotherapy.Biological determinants of radioresistance and their remediation in pancreatic cancer.Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation.Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests.Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro.Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system.Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin.Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery.Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.
P2860
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P2860
Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Radioresistance of K-Ras mutat ...... ctivation of PI3K-AKT pathway.
@en
type
label
Radioresistance of K-Ras mutat ...... ctivation of PI3K-AKT pathway.
@en
prefLabel
Radioresistance of K-Ras mutat ...... ctivation of PI3K-AKT pathway.
@en
P2093
P1476
Radioresistance of K-Ras mutat ...... ctivation of PI3K-AKT pathway.
@en
P2093
H Peter Rodemann
Klaus Dittmann
Mahmoud Toulany
Maren Krüger
P304
P356
10.1016/J.RADONC.2005.06.024
P577
2005-08-01T00:00:00Z