about
Molecular motors implicated in the axonal transport of tau and alpha-synucleinCritical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.Dynamic association of tau with neuronal membranes is regulated by phosphorylation.Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.Chicken synucleins: cloning and expression in the developing embryo.Roles of tau protein in health and disease.Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionKey issues in the acquisition and analysis of qualitative and quantitative mass spectrometry data for peptide-centric proteomic experiments.Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.Advances in tau-based drug discovery.The microtubule-associated protein tau is phosphorylated by SykUpregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease.The importance of tau phosphorylation for neurodegenerative diseasesTau phosphorylation: the therapeutic challenge for neurodegenerative disease.Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfoldingThe microtubule-associated protein tau is also phosphorylated on tyrosine.Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease.Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.Functional implications of the association of tau with the plasma membrane.Tau cleavage and tau aggregation in neurodegenerative disease.Functional implications of glycogen synthase kinase-3-mediated tau phosphorylationA role for tau at the synapse in Alzheimer's disease pathogenesis.Intracellular and extracellular roles for tau in neurodegenerative disease.NUB1 modulation of GSK3β reduces tau aggregation.Physiological release of endogenous tau is stimulated by neuronal activity.Fluconazole and testosterone: in vivo and in vitro studies.Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts.Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies.ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's diseaseAlzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.Anti-inflammatory impact of minocycline in a mouse model of tauopathy.Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β.Tau phosphorylation affects its axonal transport and degradation.
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description
hulumtuese
@sq
onderzoeker
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researcher
@en
հետազոտող
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name
Diane P. Hanger
@ast
Diane P. Hanger
@en
Diane P. Hanger
@es
Diane P. Hanger
@sl
type
label
Diane P. Hanger
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Diane P. Hanger
@en
Diane P. Hanger
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Diane P. Hanger
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D P Hanger
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Diane Hanger
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Diane P. Hanger
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Diane P. Hanger
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Diane P. Hanger
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Diane P. Hanger
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P1053
C-5697-2009
P106
P1153
6603978522
P21
P31
P3829
P3835
diane-hanger
P496
0000-0002-3044-9816