Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections.
about
1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PRUnique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitorAntiviral properties of caffeic acid phenethyl ester and its potential applicationMechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTPStructure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptaseStability-activity relationships of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors. A basis for anti-HIV drug designAnalysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivoDiarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitorsAntiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newbNovel compounds in preclinical/early clinical development for the treatment of HIV infections.Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers.Developing G-quartet oligonucleotides as novel anti-HIV agents: focus on anti-HIV drug design.Anti-HIV activity of medicinal herbs: usage and potential development.Delivery of novel macromolecular drugs against HIV-1.Considerations and development of topical microbicides to inhibit the sexual transmission of HIV.In search of authentic inhibitors of HIV-1 integration.New anti-HIV agents and targets.Dimerization inhibitors of HIV-1 protease.Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.In search of a selective antiviral chemotherapy.A concise synthesis of 3-(1-alkenyl)isoindolin-1-ones and 5-(1-alkenyl)pyrrol-2-ones by the intermolecular coupling reactions of N-acyliminium ions with unactivated olefins(E)-Methyl 3-(3,4-dimeth-oxy-phen-yl)-2-[(1,3-dioxoisoindolin-2-yl)meth-yl]acrylate.(E)-Methyl 2-[(1,3-dioxoisoindolin-2-yl)meth-yl]-3-phenyl-acrylateDevelopment of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutationsSynthesis and anti-HIV activity of D- and L-thietanose nucleosides.Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors.Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in Vitro.Targeting RNase L to human immunodeficiency virus RNA with 2-5A-antisense.Bovine colostrum: an emerging nutraceutical.Microwave-assisted synthesis of chromenes: biological and chemical importance.A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.Efficacy of antiviral chemotherapy for retrovirus-infected cats: What does the current literature tell us?Cell-based fluorescence assay for human immunodeficiency virus type 1 protease activityDeoxyribonucleotide-containing RNAs: a novel class of templates for HIV-1 reverse transcriptase.Some novel aminopropyl nucleoside phosphonates.Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker.Synthesis and anti-HIV activity of some [Nucleoside Reverse Transcriptase Inhibitor]-C5'-linker-[Integrase Inhibitor] heterodimers as inhibitors of HIV replication.Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
P2860
Q27629375-C111BD3C-1CA0-4F0D-B11A-22D561A311D0Q27735940-FE6C9593-E371-4292-B624-46BAC168DB44Q28081546-D3614ABA-A0FB-4857-8E4B-EA970E6F5D4AQ28343830-FA8BC65C-EC90-432D-890F-62C42170DA9FQ28369309-1C6C1734-8434-409E-A208-C9B1BD3E9591Q28369425-2CD9EED5-D7FF-4F58-809F-C72790D745DFQ28379312-7ADF53E3-7472-4870-80BF-2E2AB65FCA8DQ28379464-0C1CF58C-05B4-44CA-992D-28E360056171Q28379501-C7353CAB-3AB5-4B99-9AC1-F3CDF6893130Q33966254-F32CCEAF-6422-4AB1-8773-BCF0F0DFC0FBQ33979799-57D3AE31-CF93-4F99-9F06-6D693EFFF24DQ34075007-A5E33B66-1EC5-4318-BE4F-7DD584840A4FQ34231016-2557EBD6-C91B-4312-8FE7-37CC98F6DD06Q34452681-A7BAF956-6616-46AA-AE06-ED3DF27B1C18Q34768558-BDF4A401-9E3C-47F6-8073-E01A6921649EQ34785977-814DDB5B-32BC-4FCA-B014-E4E325C623EAQ34944447-58C76AE4-5254-452C-AFE7-273F87D68C62Q35000755-C9031EB0-EE77-480A-8DC8-F6507035A0A8Q35137562-10672460-3E99-4B1C-A82E-8A6825ED01D5Q35375912-69F0CE16-7478-4009-9F08-D5ACEC599050Q35825514-1301842D-8E44-4AC6-993E-3EFBF9B2A406Q35933428-FE969837-308D-48B2-8313-D53429FFCFD3Q36087716-ED626610-F422-4838-B96F-E04E94D445A2Q36538764-F9DC2701-038A-42AD-8F50-DE20A0781030Q36870669-84DE3E21-5986-49FB-B1F9-584247CB5F60Q37399117-2C94B942-B14B-4550-ABEE-FF68CE24120AQ37451242-CE20C4B3-3DB3-41F7-8D3C-823EE09C81C9Q38032909-F0BCACC5-BA78-4F6D-818D-9E187D7CF102Q38312462-40EE72D8-D717-4024-BF8B-941FA344BA92Q38329856-AA8F8794-93FE-4EB8-8C11-26675D1ADD7DQ38381533-C0BDFF5E-AC6E-4ACA-BF3A-88311FE67393Q38523596-BD46C49F-9204-456A-8CFE-B8BD1E4316D4Q38586576-8C81B9A3-1096-4C6A-B5F7-85B675AF2E57Q38612672-87EA02CD-C366-4122-A702-87FFA10137B8Q39478324-97FD8C98-99E9-4950-877B-F1291AE6E112Q39721728-DB70B983-5318-40AF-AF4A-182A7F41A295Q40037913-AFD776F9-9AA1-4C77-B2CE-49B845929A64Q40045544-55D49AC6-5769-4B52-B24A-661557375E4AQ40468069-9FA6D5C3-42EC-45C3-A8FA-EAF2FFAF6FC8Q40544780-D390D258-2F91-4299-8DA8-CD5EA077F0A9
P2860
Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Toward improved anti-HIV chemo ...... ervention with HIV infections.
@en
type
label
Toward improved anti-HIV chemo ...... ervention with HIV infections.
@en
prefLabel
Toward improved anti-HIV chemo ...... ervention with HIV infections.
@en
P356
P1476
Toward improved anti-HIV chemo ...... ervention with HIV infections.
@en
P2093
De Clercq E
P304
P356
10.1021/JM00014A001
P407
P577
1995-07-01T00:00:00Z