A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes.
about
The P2X7 receptor is a key modulator of aerobic glycolysisPurinergic signalling and cancerPolymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal womenInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsDifferential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptorA common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular eventsCloning and pharmacological characterization of the guinea pig P2X7 receptor orthologueCloning and pharmacological characterization of the dog P2X7 receptor.Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.The role of the P2X₇ receptor in infectious diseases.Corneal epithelium expresses a variant of P2X(7) receptor in health and diseaseNon-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkersThe hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice.Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.Possible protective role of the 489C>T P2X7R polymorphism in Alzheimer's disease.The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis.Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions.Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor FunctionSingle-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fracturesP2X receptor characterization and IL-1/IL-1Ra release from human endothelial cellsModulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule.The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.P2X(7) receptors: properties and relevance to CNS function.A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerizationAssociation of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain statesSusceptibility genes and B-chronic lymphocytic leukaemia.P2 purinergic receptor modulation of cytokine production.Inhibition of P2X(7) receptors by divalent cations: old action and new insight.PKC-dependent ERK phosphorylation is essential for P2X7 receptor-mediated neuronal differentiation of neural progenitor cellsCell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor traffickingExpression, signaling, and function of P2X7 receptors in bone.P2X7 receptors in oligodendrocytes: a novel target for neuroprotection.Autocrine regulation of T-cell activation by ATP release and P2X7 receptors.The P2X(7) receptor and intracellular pathogens: a continuing struggle.Genetics of the P2X7 receptor and human disease.Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients.Correlation between P2X7 receptor gene polymorphisms and gout.
P2860
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P2860
A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A His-155 to Tyr polymorphism ...... of human leukemic lymphocytes.
@en
type
label
A His-155 to Tyr polymorphism ...... of human leukemic lymphocytes.
@en
prefLabel
A His-155 to Tyr polymorphism ...... of human leukemic lymphocytes.
@en
P2093
P1476
A His-155 to Tyr polymorphism ...... of human leukemic lymphocytes
@en
P2093
Alessandra Balboni
Antonio Cuneo
Gianluigi Castoldi
O Roberto Baricordi
Paola Agostini
Patrizia Pellegatti
Simonetta Falzoni
Sylvia L Forchap
P356
10.4049/JIMMUNOL.175.1.82
P407
P577
2005-07-01T00:00:00Z