The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. - Wikidata - awgldk - TriplyDB

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

http://www.wikidata.org/entity/Q40414479

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Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress Primitive hematopoietic cells resist HIV-1 infection via p21 A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases Ginseng: a promising neuroprotective strategy in stroke Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin The complexity of the Nrf2 pathway: beyond the antioxidant response Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.NADPH oxidase limits innate immune responses in the lungs in mice A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses Nrf2 activation protects the liver from ischemia/reperfusion injury in mice Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease Regenerative stromal cell therapy in allogeneic hematopoietic stem cell transplantation: current impact and future directions.Heme oxygenase-1 dysregulation in the brain: implications for HIV-associated neurocognitive disorders.The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.Cancer chemoprevention: scientific promise, clinical uncertainty.Targeting maladaptive glutathione responses in lung disease.Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing.Neuroprotective strategies involving ROS in Alzheimer disease.CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.Targeting NRF2 signaling for cancer chemoprevention.Screening of natural compounds as activators of the keap1-nrf2 pathway.Unraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione.NRF2 deficiency reduces life span of mice administered thoracic irradiation.Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β -Cell Damage.Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

http://www.wikidata.org/entity/Q40414479

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2005 nî lūn-bûn

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The synthetic triterpenoids, C ...... nase-1 and Nrf2/ARE signaling.

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Andrew E Place

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Anupam Agarwal

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Charlotte R Williams

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Darlene B Royce

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Gordon W Gribble

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Mark M Yore

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Michael B Sporn

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Nanjoo Suh

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Renee Risingsong

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4789-4798

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10.1158/0008-5472.CAN-04-4539

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11

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