Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
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Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseAssembly, trafficking and function of gamma-secretaseExtensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's diseaseModulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.The Alzheimer's disease beta-secretase enzyme, BACE1.Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models.LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidFunctional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease.Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.The role of lipoprotein receptors on the physiological function of APP.The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells.Physiological and pathological roles of the γ-secretase complex.Functional Roles of the Interaction of APP and Lipoprotein Receptors.Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies.Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease.SorLA signaling by regulated intramembrane proteolysis.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.
P2860
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P2860
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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name
Low density lipoprotein recept ...... ein (APP) for gamma-secretase.
@en
type
label
Low density lipoprotein recept ...... ein (APP) for gamma-secretase.
@en
prefLabel
Low density lipoprotein recept ...... ein (APP) for gamma-secretase.
@en
P2093
P2860
P356
P1476
Low density lipoprotein recept ...... ein (APP) for gamma-secretase.
@en
P2093
Alberto Lleó
Christine A F von Arnim
Claus U Pietrzik
Dudley K Strickland
Edward H Koo
Elaine Waldron
Lauren Herl
Michele M Tangredi
Oksana Berezovska
P2860
P304
27303-27309
P356
10.1074/JBC.M413969200
P407
P577
2005-05-25T00:00:00Z