The F(ab)'2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain.
about
Active and passive immunotherapy for neurodegenerative disordersGermline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragmentFirst-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer's disease.Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chainsAbeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.Amyloid-beta immunotherapy for Alzheimer's diseaseProphylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.Immunization in Alzheimer's disease: naïve hope or realistic clinical potential?Antibody-based therapy in Alzheimer's disease.Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies.Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies.Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy.A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies.In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques.MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic miceSelective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Abeta42 for magnetic resonance molecular imaging.Antibody blood-brain barrier efflux is modulated by glycan modification.Antibodies bound to Aβ oligomers potentiate the neurotoxicity of Aβ by activating microglia.
P2860
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P2860
The F(ab)'2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The F(ab)'2 fragment of an Abe ...... s Abeta deposits in the brain.
@en
type
label
The F(ab)'2 fragment of an Abe ...... s Abeta deposits in the brain.
@en
prefLabel
The F(ab)'2 fragment of an Abe ...... s Abeta deposits in the brain.
@en
P2093
P1476
The F(ab)'2 fragment of an Abe ...... s Abeta deposits in the brain.
@en
P2093
Dennis Klinman
Ke-Qin Xin
Kenji Hamajima
Kenji Okuda
Kiyohiko Matsui
Masato Narita
Nobuyoshii Tajima
Shunsuke Yanoma
Yuichi Tamura
P304
P356
10.1016/J.NBD.2005.04.007
P577
2005-11-01T00:00:00Z