Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.
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Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasisRole of ZAC1 in transient neonatal diabetes mellitus and glucose metabolismPPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunctionResearch resource: nuclear hormone receptor expression in the endocrine pancreasThe protective effect of berberine on β-cell lipoapoptosis.MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice.Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cellsPPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cellsEvaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function.Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.Alteration of mitochondrial function in adult rat offspring of malnourished dams.Expression of PPARalpha modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice.Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy MetabolismRosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets.Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes.Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis.Retinoids: Potent regulators of metabolism.Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?Redefining the role of thiazolidinediones in the management of type 2 diabetesMolecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation.Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery.Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells.Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate.Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.Antidiabetic and Hypolipidemic Activities of Curculigo latifolia Fruit:Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats.The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment.Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects.Maternal diets deficient in folic acid and related methyl donors modify mechanisms associated with lipid metabolism in the fetal liver of the rat.PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.
P2860
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P2860
Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Peroxisome proliferator-activa ...... tion in pancreatic beta-cells.
@en
type
label
Peroxisome proliferator-activa ...... tion in pancreatic beta-cells.
@en
prefLabel
Peroxisome proliferator-activa ...... tion in pancreatic beta-cells.
@en
P2093
P356
P1433
P1476
Peroxisome proliferator-activa ...... tion in pancreatic beta-cells.
@en
P2093
Blanca Rubi
Jakob Fridriksson
Jan K Larsen
Kim Ravnskjaer
Michael Boergesen
Tina Nielsen
P304
P356
10.1210/EN.2004-1430
P407
P577
2005-05-05T00:00:00Z