Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.
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Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionMechanism of Action and Applications of Interleukin 24 in ImmunotherapyRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.The development of MDA-7/IL-24 as a cancer therapeuticPrognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patientsThe stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineStress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancerDevelopment of Ad-mda7/IL-24-resistant lung cancer cell lines.dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing.TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2.Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios.Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance.Naturally occurring, tumor-specific, therapeutic proteins.Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities.Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activityThe PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo.ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replicationThe antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer.PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members.eIF2α Phosphorylation Mediates IL24-Induced Apoptosis through Inhibition of Translation.
P2860
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P2860
Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Melanoma differentiation-assoc ...... -activated protein kinase PKR.
@en
type
label
Melanoma differentiation-assoc ...... -activated protein kinase PKR.
@en
prefLabel
Melanoma differentiation-assoc ...... -activated protein kinase PKR.
@en
P2093
P1433
P1476
Melanoma differentiation-assoc ...... -activated protein kinase PKR.
@en
P2093
Abujiang Pataer
Glen N Barber
Jack A Roth
Kelly K Hunt
Siddharth Balachandran
Stephan A Vorburger
Stephen G Swisher
Sunil Chada
P304
P356
10.1016/J.YMTHE.2005.01.018
P577
2005-05-01T00:00:00Z