Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
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Molecular Insight in the Multifunctional Effects of OridoninDisruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancerDiscovery and development of natural product oridonin-inspired anticancer agentsSelection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approachOridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line.Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaBOridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-mycOridonin: targeting programmed cell death pathways as an anti-tumour agent.ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoidsOridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway.Anti-cancer natural products isolated from chinese medicinal herbsBharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling.Compromising σ-1 receptors at the endoplasmic reticulum render cytotoxicity to physiologically relevant concentrations of dopamine in a nuclear factor-κB/Bcl-2-dependent mechanism: potential relevance to Parkinson's diseaseSpecific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice.NF-kappaB in pathogenesis and treatment of adult T-cell leukemia/lymphoma.Role of LM23 in cell proliferation and apoptosis and its expression during the testis developmentInvestigation of the anti‑asthmatic activity of Oridonin on a mouse model of asthma.Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter.Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosisOridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cellsDirect Rel/NF-κB inhibitors: structural basis for mechanism of action.Luminescent detection of DNA-binding proteins.Targeting HTLV-1 activation of NFκB in mouse models and ATLL patients.Terpenoids: natural products for cancer therapy.Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin.Natural products against hematological malignancies and identification of their targets.Geridonin, a novel derivative of oridonin, inhibits proliferation of MGC 803 cells both in vitro and in vivo through elevating the intracellular ROS.Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryiReactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma.Sensitization to TRAIL-induced apoptosis in human neuroblastoma SK-N-AS cells by NF-κB inhibitors is dependent on reactive oxygen species (ROS).Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals.A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies.Down-regulation of androgen-receptor and PSA by phytochemicals.Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors.Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin.IL-1β inhibits self-renewal capacity of dormant CD34⁺/CD38⁻ acute myelogenous leukemia cells in vitro and in vivo.Role of NF-κB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro.Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway.Phytotherapeutics Oridonin and Ponicidin show Additive Effects Combined with Irradiation in Pancreatic Cancer in Vitro.
P2860
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P2860
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Oridonin, a diterpenoid purifi ...... he NF-kappa B signal pathways.
@en
type
label
Oridonin, a diterpenoid purifi ...... he NF-kappa B signal pathways.
@en
prefLabel
Oridonin, a diterpenoid purifi ...... he NF-kappa B signal pathways.
@en
P2093
P1476
Oridonin, a diterpenoid purifi ...... he NF-kappa B signal pathways.
@en
P2093
H Phillip Koeffler
Hirokuni Taguchi
Hisanori Machida
Kazuto Togitani
Kentaro Bandobashi
Takayuki Ikezoe
Tsuyako Saito
P304
P356
10.1158/1535-7163.MCT-04-0277
P577
2005-04-01T00:00:00Z