about
Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance managementAcetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarityStructural genomics for drug design against the pathogen Coxiella burnetiiAntidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.Discovery of non-zwitterionic GABA(A) receptor full agonists and a superagonist.Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron).Pd-catalyzed amination as an alternative to nucleophilic aromatic substitution for the synthesis of N-alkyltacrines and analogues.Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studiesCarbamate and pyrethroid resistance in the akron strain of Anopheles gambiaeAccess to "Friedel-Crafts-restricted" tert-alkyl aromatics by activation/methylation of tertiary benzylic alcohols.Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiaeEffects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine AcetylcholinesteraseInhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi.Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue.Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action.Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations.Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant.Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.Axial-selective H/D exchange of glycine-derived 1H-benzo[e][1,4]diazepin-2(3H)-ones: kinetic and computational studies of enantiomerization.Toxicology of potassium channel-directed compounds in mosquitoes.Computational studies of ion-pair separation of benzylic organolithium compounds in THF: importance of explicit and implicit solvation.Regioselective synthesis of aniline-derived 1,3- and Ci-symmetric 1,4-diols from trans-1,4-cyclohexadiene dioxide.Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones.Stereochemical inversion of a cyano-stabilized grignard reagent: remarkable effects of the ethereal solvent structure and concentration.Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.Catalytic asymmetric synthesis of protected tryptophan regioisomers.Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae.Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae.Immobilized enzymes as catalytically-active tools for nanofabrication.Configurational stability of chiral lithiated cyclopropylnitriles: a density functional study.Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality.
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description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Paul R. Carlier
@ast
Paul R. Carlier
@en
Paul R. Carlier
@es
Paul R. Carlier
@nl
Paul R. Carlier
@sl
type
label
Paul R. Carlier
@ast
Paul R. Carlier
@en
Paul R. Carlier
@es
Paul R. Carlier
@nl
Paul R. Carlier
@sl
prefLabel
Paul R. Carlier
@ast
Paul R. Carlier
@en
Paul R. Carlier
@es
Paul R. Carlier
@nl
Paul R. Carlier
@sl
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P106
P1153
7102383847
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P31
P496
0000-0002-6683-285X