Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
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Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprogramingExploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.Cell metabolism: an essential link between cell growth and apoptosisDifferential protein expression profiles in estrogen receptor-positive and -negative breast cancer tissues using label-free quantitative proteomics.Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.HIF1α is required for survival maintenance of chronic myeloid leukemia stem cellsRac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.Metabolic stress in autophagy and cell death pathwaysHepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance.Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.The promise of PET in clinical management and as a sensitive test for drug cytotoxicity in sarcomas.The role of mitochondrial DNA damage and repair in the resistance of BCR/ABL-expressing cells to tyrosine kinase inhibitorsSelective anticancer strategies via intervention of the death pathways relevant to cell transformation.Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cellsCanonical and new generation anticancer drugs also target energy metabolism.Tyrosine kinase inhibitors under investigation for the treatment of type II diabetes.Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.Optimization of tumor xenograft dissociation for the profiling of cell surface markers and nutrient transporters.S6K1 determines the metabolic requirements for BCR-ABL survival.Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by H NMR spectroscopy.Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice.Metabolic characterization of imatinib-resistant BCR-ABL T315I chronic myeloid leukemia cells indicates down-regulation of glycolytic pathway and low ROS production.Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells.Effect of drug-induced cytotoxicity on glucose uptake in Hodgkin's lymphoma cells.New roles for pyruvate kinase M2: working out the Warburg effect.Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometerAerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.Therapeutic effect of sunitinib malate and its influence on blood glucose concentrations in a patient with metastatic insulinoma.The relevance of tyrosine kinase inhibitors for global metabolic pathways in cancer.Monitoring tyrosine kinase inhibitor therapeutic responses with a panel of metabolic biomarkers in chronic myeloid leukemia patients.Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
P2860
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P2860
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Chronic myeloid leukaemia: an ...... glucose transport regulation.
@en
type
label
Chronic myeloid leukaemia: an ...... glucose transport regulation.
@en
altLabel
Chronic myeloid leukaemia: an ...... n glucose transport regulation
@en
prefLabel
Chronic myeloid leukaemia: an ...... glucose transport regulation.
@en
P2093
P2860
P50
P356
P1433
P1476
Chronic myeloid leukaemia: an ...... glucose transport regulation.
@en
P2093
Elizabeth McIntosh
Johanne Bentley
Kay Barnes
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208461
P407
P577
2005-05-01T00:00:00Z
P5875
P6179
1009227848