about
Tumor microenvironment: regulatory cells and immunosuppressive cytokinesThe receptor NLRP3 is a transcriptional regulator of TH2 differentiationBleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cellsMembrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cellsLiver X receptor β activation induces pyroptosis of human and murine colon cancer cellsProduction of adenosine by ectonucleotidases: a key factor in tumor immunoescape.The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.Transcriptome analysis of TH2 CD4(+) T cells differentiated from wild-type and NLRP3KO mice.
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