Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.
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Natural polyphenols: Influence on membrane transportersMultidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane VesiclesRecent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapiesMutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways.Sensitization to docetaxel in prostate cancer cells by green tea and quercetin.Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.A structure-activity relationship study of ABCC2 inhibitors.Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds.Virtual screening of ABCC1 transporter nucleotidebinding domains as a therapeutic target in multidrug resistant cancer.Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells.Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions.Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.Improving metabolic stability of cancer chemoprotective polyphenols.Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4Modeling kinetics of subcellular disposition of chemicals.Impact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in ratsBioactivity and structure of biophenols as mediators of chronic diseases.Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea.Advancement of structure-activity relationship of multidrug resistance-associated protein 2 interactions.Flavonoid-induced glutathione depletion: potential implications for cancer treatmentSelected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion.Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs.Interference of flavonoids with fluorescent intracellular probes: methodological implications in the evaluation of the oxidative burst by flow cytometry.Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure-activity/property relationship-based approach in the study of bioavailability and bioactivity.Modulators of the human ABCC2: hope from natural sources?The therapeutic potential of targeting ABC transporters to combat multi-drug resistance.Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells.Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition.Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms.Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin.Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids.Prediction of biliary excretion in rats and humans using molecular weight and quantitative structure-pharmacokinetic relationships.Effects of natural products on the function of human organic anion transporting polypeptide 1B1.Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid.Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.P-gp efflux pump inhibition potential of common environmental contaminants determined in vitro.Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats.
P2860
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P2860
Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Quantitative structure activit ...... g resistance proteins 1 and 2.
@en
type
label
Quantitative structure activit ...... g resistance proteins 1 and 2.
@en
prefLabel
Quantitative structure activit ...... g resistance proteins 1 and 2.
@en
P2093
P1476
Quantitative structure activit ...... ug resistance proteins 1 and 2
@en
P2093
Heleen M Wortelboer
Jelmer J van Zanden
Mustafa Usta
Nicole H P Cnubben
Peter J van Bladeren
Sabina Bijlsma
P304
P356
10.1016/J.BCP.2004.11.002
P407
P577
2004-12-23T00:00:00Z