RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.
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Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS SitesNatural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approachesNKG2D ligands as therapeutic targetsTGF-β signaling and its targeting for glioma treatmentTGFbeta in CancerDrug development against metastasis-related genes and their pathways: A rationale for cancer therapyRefining indications for the use of mitomycin C using a randomized controlled trial with an animal model.Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions.Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells.Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines.TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progressionHuman tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.Interleukin 10 decreases MICA expression on melanoma cell surface.TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistenceMicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape.Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cureLactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitroImmune profiling and cancer post transplantationT cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer.Enhanced NK cell adoptive antitumor effects against breast cancer in vitro via blockade of the transforming growth factor-β signaling pathwayCellular and functional characterization of immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes reveals their up-regulated synthesis of biologically active TGF-beta.A High-Throughput Assay for Screening of Natural Products that Enhanced Tumoricidal Activity of NK CellsGenetic strategies for brain tumor therapy.The cancer stem cell subtype determines immune infiltration of glioblastoma.Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis.4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cellsRNAi based approaches to the treatment of malignant glioma.Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma.The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression.A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer BiologyDendritic cell-based active specific immunotherapy for malignant glioma.An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.TGF-β1 regulates the invasive and metastatic potential of mucoepidermoid carcinoma cellsMolecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.The influence of miR-34a expression on stemness and cytotoxic susceptibility of breast cancer stem cellsPPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion.HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significanceNK cells and cancer immunosurveillance.NKG2D ligands in tumor immunity.
P2860
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P2860
RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
RNA interference targeting tra ...... ogates tumorigenicity in vivo.
@en
type
label
RNA interference targeting tra ...... ogates tumorigenicity in vivo.
@en
prefLabel
RNA interference targeting tra ...... ogates tumorigenicity in vivo.
@en
P2093
P50
P1433
P1476
RNA interference targeting tra ...... ogates tumorigenicity in vivo.
@en
P2093
Günter Eisele
Manuel A Friese
Markus Weiler
P304
P356
10.1158/0008-5472.CAN-04-1627
P407
P577
2004-10-01T00:00:00Z