Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
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A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.Vascular Endothelial Regulation of Obesity-Associated Insulin Resistance.Family history of type 2 diabetes, abdominal adipocyte size and markers of the metabolic syndrome.10 Years of GWAS Discovery: Biology, Function, and Translation.Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.Adipose tissue: between the extremes.Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations.A multitrait GWAS sheds light on insulin resistance.Genetic and epigenetic studies of adiposity and cardiometabolic disease.Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study.Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges.Metabolomic analysis of insulin resistance across different mouse strains and diets.Maternal diabetes and incidence of childhood cancer - a nationwide cohort study and exploratory genetic analysis.Bone mineral density in familial partial lipodystrophy.Trials and Tribulations of CETP Inhibitors.Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort.Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model.Comparison of adiposity indicators associated with fasting-state insulinemia, triglyceridemia, and related risk biomarkers in a nationally representative, adult population.Genetic aetiology of glycaemic traits: approaches and insights.Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight.Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population.Association between single nucleotide polymorphism rs11057401 of CCDC92 gene and the risk of coronary heart disease (CHD).Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives.Lipodystrophic laminopathies: Diagnostic clues.A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.Recent Advances in Human Genetics and Epigenetics of Adiposity: Pathway to Precision Medicine?Insulin action and resistance in obesity and type 2 diabetes.De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications.Implications of publicly available genomic data resources in searching for therapeutic targets of obesity and type 2 diabetes.Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance.
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P2860
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Integrative genomic analysis i ...... s of human insulin resistance.
@en
type
label
Integrative genomic analysis i ...... s of human insulin resistance.
@en
prefLabel
Integrative genomic analysis i ...... s of human insulin resistance.
@en
P2093
P2860
P50
P356
P1433
P1476
Integrative genomic analysis i ...... s of human insulin resistance.
@en
P2093
Andrew D Johnson
Cambridge FPLD1 Consortium
Claire Adams
EPIC-InterAct Consortium
Emanuella De Lucia Rolfe
Emmanouil Dermitzakis
Isobel D Stewart
Jian'an Luan
John D Eicher
John R B Perry
P2860
P2888
P356
10.1038/NG.3714
P407
P50
P577
2016-11-14T00:00:00Z
P6179
1022792635