hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
about
HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytesComparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomeraseDifferences in telomerase activity between colon and rectal cancerMechanism of telomerase activation by v-Rel and its contribution to transformation.Alternative splicing regulation of telomerase: a new paradigm?Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regenerationAggressive periodontitis: An appraisal of systemic effects on its etiology-genetic aspect.TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.Improving cell therapy--experiments using transplanted telomerase-immortalized cells in immunodeficient miceEts2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.p53 targets identified by protein expression profilingSaccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomeraseTelomerase: a potential therapeutic target for cancer.Tanshinones: sources, pharmacokinetics and anti-cancer activitiesLong-lived cancer-resistant rodents as new model species for cancer research.Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer.Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells.hTERT promotes cell adhesion and migration independent of telomerase activity.The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosisLatent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes.Clinical implications of antitelomeric drugs with respect to the nontelomeric functions of telomerase in cancerExtracting extra-telomeric phenotypes from telomerase mouse models.Structure-function relationships in telomerase genes.Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expressionAn investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells.Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells.Epstein-Barr virus and telomerase: from cell immortalization to therapy.Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications.Non-telomeric activities of telomerase.Telomeres, telomerase and colorectal cancer.Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis.MST-312 induces G2/M cell cycle arrest and apoptosis in APL cells through inhibition of telomerase activity and suppression of NF-κB pathway.Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells.Human Telomerase Reverse Transcriptase (hTERT) Positively Regulates 26S Proteasome Activity.ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.Development of a Sleeping Beauty-based telomerase gene delivery system for hepatocytes.Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT.Immortalization of neural precursors when telomerase is overexpressed in embryonal carcinomas and stem cells.Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells.Amino-bisphosphonates decrease hTERT gene expression in breast cancer in vitro.
P2860
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P2860
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
@en
type
label
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
@en
prefLabel
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
@en
P2093
P2860
P356
P1433
P1476
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
@en
P2093
Klas G Wiman
Leena Latonen
Rubaiyat Rahman
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208232
P407
P577
2005-02-01T00:00:00Z
P5875
P6179
1027160543