Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway.
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PEGylation of Interferon-β-1aNovel Alpha Interferon (IFN- ) Variant with Improved Inhibitory Activity against Hepatitis C Virus Genotype 1 Replication Compared to IFN- 2b Therapy in a Subgenomic Replicon SystemStable high volumetric production of glycosylated human recombinant IFNalpha2b in HEK293 cells.Emerging PEGylated drugs.Polarized secretion of interleukin (IL)-6 and IL-8 by human airway epithelia 16HBE14o- cells in response to cationic polypeptide challenge.Applications of high content screening in life science researchSortase-catalyzed transformations that improve the properties of cytokinesInterferon-λ1 linked to a stabilized dimer of Fab potently enhances both antitumor and antiviral activities in targeted cells.Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway.Synthesis of Mono-PEGylated Growth Hormone Releasing Peptide-2 and Investigation of its Biological Activity.NMEGylation: a novel modification to enhance the bioavailability of therapeutic peptides.Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells.Nanomedicines in the treatment of patients with hepatitis C co-infected with HIV--focus on pegylated interferon-alpha.Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood monocytes (PBMC) of hepatitis C patients during the first 10 weeks of treatment.Pegylated IFN-alpha2b plus ribavirin for treatment-naive patients coinfected with HCV and HIV.Role of the nurse practitioner in the management of patients with chronic hepatitis C.Site-specific PEGylation of therapeutic proteins via optimization of both accessible reactive amino acid residues and PEG derivatives.Design of an efficient medium for heterologous protein production in Yarrowia lipolytica: case of human interferon alpha 2b.PEGylated human plasma fibronectin is proteolytically stable, supports cell adhesion, cell migration, focal adhesion assembly, and fibronectin fibrillogenesis.Scientific rationale and study design of the individualized dosing efficacy vs flat dosing to assess optimal pegylated interferon therapy (IDEAL) trial: determining optimal dosing in patients with genotype 1 chronic hepatitis C.Targeted delivery of interferon-α to hepatitis B virus-infected cells using T-cell receptor-like antibodies.A comparative study of polyethylene glycol hydrogels derivatized with the RGD peptide and the cell-binding domain of fibronectin.Interferon dimers: IFN-PEG-IFN.Polymer Brushes by Atom Transfer Radical Polymerization
P2860
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P2860
Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Site of pegylation and polyeth ...... he JAK/STAT signaling pathway.
@en
type
label
Site of pegylation and polyeth ...... he JAK/STAT signaling pathway.
@en
prefLabel
Site of pegylation and polyeth ...... he JAK/STAT signaling pathway.
@en
P2093
P2860
P356
P1476
Site of pegylation and polyeth ...... he JAK/STAT signaling pathway.
@en
P2093
Constance Cullen
David Wylie
Diana Brassard
Jeffrey Chapman
Jeffrey Spond
Marc Delorenzo
Marcio Voloch
Michael J Grace
Ronald Bordens
P2860
P304
P356
10.1074/JBC.M412134200
P407
P577
2004-12-13T00:00:00Z