The Phox2B homeobox gene is mutated in sporadic neuroblastomas.
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Identification of ALK as a major familial neuroblastoma predisposition geneCell Proliferation in NeuroblastomaDistinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish modelsRegorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy ModelsAutonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expressionCADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma.Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastomaDepletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome.Targeting MYCN in neuroblastoma by BET bromodomain inhibitionMYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma developmentCarbon dioxide chemoreception and hypoventilation syndromes with autonomic dysregulation.The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.The MYCN Protein in Health and Disease.Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.A 6-gene signature identifies four molecular subgroups of neuroblastomaTargeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth.Identification of the genetic and clinical characteristics of neuroblastomas using genome-wide analysis.Structural and functional differences in PHOX2B frameshift mutations underlie isolated or syndromic congenital central hypoventilation syndrome.Cell death-based treatment of neuroblastoma.Examination of PHOX2B in adult neuroendocrine neoplasms reveals relatively frequent expression in phaeochromocytomas and paragangliomas.Modeling cancer using patient-derived induced pluripotent stem cells to understand development of childhood malignancies.
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P2860
The Phox2B homeobox gene is mutated in sporadic neuroblastomas.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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name
The Phox2B homeobox gene is mutated in sporadic neuroblastomas.
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type
label
The Phox2B homeobox gene is mutated in sporadic neuroblastomas.
@en
prefLabel
The Phox2B homeobox gene is mutated in sporadic neuroblastomas.
@en
P2093
P2860
P356
P1433
P1476
The Phox2B homeobox gene is mutated in sporadic neuroblastomas.
@en
P2093
Alexander Schramm
Alvin Chan
Angelika Eggert
Arjan van Lakeman
Huib Caron
Max van Noesel
Peter Sluis
Vera van Limpt
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208157
P407
P577
2004-12-01T00:00:00Z
P5875
P6179
1038620394