Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes.
about
B-cell-specific DNA binding by an E47 homodimerAutoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoterRegulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cellsMembers of the large Maf transcription family regulate insulin gene transcription in islet beta cellsGlucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localizationRegulation of the insulin gene by glucose and fatty acidsDifferential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2.p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter.The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein bindingComputational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutantsRestricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation.Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxesPancreatic beta cells express a diverse set of homeobox genes.A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured isletsLocalization of E2A mRNA expression in developing and adult rat tissuesThe E2A gene product contains two separable and functionally distinct transcription activation domains.Homologous DNA sequences and cellular factors are implicated in the control of glucagon and insulin gene expressionBETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes.Functional characterization of the transactivation properties of the PDX-1 homeodomain protein.Pan/E2A expression precedes immunoglobulin heavy-chain expression during B lymphopoiesis in nontransformed cells, and Pan/E2A proteins are not detected in myeloid cellsCell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene.E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins.Molecular characterization of the rat insulin enhancer-binding complex 3b2. Cloning of a binding factor with putative helicase motifs.A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell linesEts proteins: new factors that regulate immunoglobulin heavy-chain gene expression.Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer.Schistosome extracts with heat shock factor activity revealed by the gel shift assay.The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer.Human insulin gene enhancer-binding proteins in pancreatic alpha and beta cell lines.Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells.An activation domain of the helix-loop-helix transcription factor E2A shows cell type preference in vivo in microinjected zebra fish embryos.Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene.B-cell factor 1 is required for optimal expression of the DRA promoter in B cells.The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes.The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.The insulin gene contains multiple transcriptional elements that respond to glucose.Basic helix-loop-helix proteins in murine type C retrovirus transcriptional regulation.
P2860
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P2860
Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Distribution and characterizat ...... ic beta cells and lymphocytes.
@en
type
label
Distribution and characterizat ...... ic beta cells and lymphocytes.
@en
prefLabel
Distribution and characterizat ...... ic beta cells and lymphocytes.
@en
P2093
P2860
P356
P1476
Distribution and characterizat ...... ic beta cells and lymphocytes.
@en
P2093
P2860
P304
P356
10.1093/NAR/19.14.3893
P577
1991-07-01T00:00:00Z