Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis.
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Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID.GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseDosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathiesInteraction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ lineDiminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice.Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in miceOrganotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor.Expression profiles of HA117 and its neighboring gene DPF3 in different colon segments of Hirschsprung's disease.Validating single-cell genomics for the study of renal development.Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell nicheSRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease.Regulation of neural development by glial cell line-derived neurotrophic factor family ligands.Male and female differential reproductive rate could explain parental transmission asymmetry of mutation origin in Hirschsprung disease.Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance.RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.Mechanistic insights into the regulation of the spermatogonial stem cell nicheTraditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations.A common RET variant is associated with reduced newborn kidney size and functionStage specific requirement of Gfrα1 in the ureteric epithelium during kidney developmentHirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.To bud or not to bud: the RET perspective in CAKUT.Balancing on the crest - Evidence for disruption of the enteric ganglia via inappropriate lineage segregation and consequences for gastrointestinal function.RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development.Role of the testis interstitial compartment in spermatogonial stem cell function.Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal.Expression variability and function of the RET gene in adult peripheral blood mononuclear cells.Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling.Immunophenotypic characterization of enteric neural crest cells in the developing avian colorectum.The many faces of RET dysfunction in kidney.The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice.Neurturin-mediated ret activation is required for retinal function.GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine.Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa.Critical and distinct roles for key RET tyrosine docking sites in renal development.
P2860
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P2860
Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Mice expressing a dominant-neg ...... ole of Ret in spermatogenesis.
@en
type
label
Mice expressing a dominant-neg ...... ole of Ret in spermatogenesis.
@en
prefLabel
Mice expressing a dominant-neg ...... ole of Ret in spermatogenesis.
@en
P2093
P356
P1433
P1476
Mice expressing a dominant-neg ...... ole of Ret in spermatogenesis.
@en
P2093
Akshay Gupta
Amy Strickland
Cathy K Naughton
Eugene M Johnson
Jeffrey Milbrandt
Judy Golden
Mario Encinas
Sanjay Jain
P304
P356
10.1242/DEV.01421
P407
P577
2004-10-06T00:00:00Z