Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
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The Cellular Prion Protein: A Player in Immunological QuiescenceMutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 SubunitMammalian prion protein suppresses Bax-induced cell death in yeastThe prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathwaysFrequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.Functionally relevant domains of the prion protein identified in vivoContext dependent neuroprotective properties of prion protein (PrP).A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.Copper binding extrinsic to the octarepeat region in the prion proteinDifferential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.Establishment and characterization of Prnp knockdown neuroblastoma cells using dual microRNA-mediated RNA interferenceThe cellular prion protein (PrP(C)): its physiological function and role in diseaseIntegrity of helix 2-helix 3 domain of the PrP protein is not mandatory for prion replication.Copper and the prion protein: methods, structures, function, and diseaseMolecular basis of cerebral neurodegeneration in prion diseases.Prion neurotoxicity: insights from prion protein mutantsHelix 3 is necessary and sufficient for prion protein's anti-Bax function.Prion proteins with pathogenic and protective mutations show similar structure and dynamics.Prion disease tempo determined by host-dependent substrate reduction.Endoproteolytic processing of the mammalian prion glycoprotein family.TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in miceA Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide.The role of the octarepeat region in neuroprotective function of the cellular prion protein.The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivoThe octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4.The affinity of copper binding to the prion protein octarepeat domain: evidence for negative cooperativity.Prion protein lacks robust cytoprotective activity in cultured cells.Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.Purkinje-cell degeneration in prion protein-deficient mice is associated with a cerebellum-specific Doppel protein species signature.
P2860
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P2860
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-my
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@zh-sg
2004年學術文章
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name
Genetic mapping of activity de ...... the Doppel helix B/B' region.
@en
type
label
Genetic mapping of activity de ...... the Doppel helix B/B' region.
@en
prefLabel
Genetic mapping of activity de ...... the Doppel helix B/B' region.
@en
P2093
P2860
P356
P1476
Genetic mapping of activity de ...... the Doppel helix B/B' region.
@en
P2093
Bettina Drisaldi
Bob Strome
David Westaway
François Major
Hans Kretzschmar
Howard T J Mount
Janaky Coomaraswamy
Joel C Watts
M Azhar Chishti
P2860
P304
55443-55454
P356
10.1074/JBC.M404794200
P407
P577
2004-09-29T00:00:00Z