A structural basis for the species-specific antagonism of 26,23-lactones on vitamin D signaling.
about
On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype.Agonist and antagonist binding to the nuclear vitamin D receptor: dynamics, mutation effects and functional implications.New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model.Inhibitors for the Vitamin D Receptor-Coregulator Interaction.Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice.Vitamin D receptor ligands: the impact of crystal structures.1alpha,25-Dihydroxyvitamin D(3)-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells.
P2860
Q33508413-214A4DC5-A3BB-4925-91B6-FC77879F24C7Q33610663-3A4CE757-A58A-430F-BBBA-EA1276521924Q34433885-3863D7F9-6AF3-4789-81E5-F0AB056187F7Q35868761-DF70D013-3D67-4A47-A490-98D790BC2C3CQ35909214-5DCF8090-3D26-4BB7-84CF-D0E94FA20D4CQ36148118-6B1236EC-55A0-4D39-AB8D-9261B9D077AFQ36305152-B34B8824-08EE-4B58-8597-BB8324BEAE61Q37997100-79171684-F3B8-4132-A5CB-561BCC62C046Q41877603-7A5DFD61-C906-413D-9EC1-578AF839940C
P2860
A structural basis for the species-specific antagonism of 26,23-lactones on vitamin D signaling.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
A structural basis for the spe ...... ctones on vitamin D signaling.
@en
type
label
A structural basis for the spe ...... ctones on vitamin D signaling.
@en
prefLabel
A structural basis for the spe ...... ctones on vitamin D signaling.
@en
P1476
A structural basis for the spe ...... actones on vitamin D signaling
@en
P2093
Mikael Peräkylä
P304
P356
10.1016/J.CHEMBIOL.2004.05.023
P577
2004-08-01T00:00:00Z