Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity.
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DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiationGenetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromiumChromium genotoxicity: A double-edged swordThe impact of environmental metals in young urbanites' brains.XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphiboleEpigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitroChromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activationXPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromateA retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-upChromium reduces the in vitro activity and fidelity of DNA replication mediated by the human cell DNA synthesome.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Cancer risk is not increased after conventional hip arthroplasty.Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.Trivalent chromium: assessing the genotoxic risk of an essential trace element and widely used human and animal nutritional supplement.DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.Chromium (VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cellsChromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cellsChromium in drinking water: sources, metabolism, and cancer risksWRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.Oral Chromium Exposure and Toxicity.Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent ChromiumDifferential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue.ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide.Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolismSignal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II).Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis.DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis.Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity.Molecular mechanisms of Cr(VI) resistance in bacteria and fungi.Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells.Polymerase η suppresses telomere defects induced by DNA damaging agentsFormaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure.Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.Cr(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck.
P2860
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P2860
Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Human nucleotide excision repa ...... lls against chromate toxicity.
@en
type
label
Human nucleotide excision repa ...... lls against chromate toxicity.
@en
prefLabel
Human nucleotide excision repa ...... lls against chromate toxicity.
@en
P2093
P2860
P356
P1476
Human nucleotide excision repa ...... lls against chromate toxicity.
@en
P2093
Anatoly Zhitkovich
Elizabeth Peterson
George Quievryn
Mindy Reynolds
P2860
P304
30419-30424
P356
10.1074/JBC.M402486200
P407
P577
2004-04-15T00:00:00Z