Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.
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Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentrationBrain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cellsAdenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensingPer-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretionAMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cellsExercise training plus metformin, but not exercise training alone, decreases insulin production and increases insulin clearance in adults with prediabetes.Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial CellsLKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMFResveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.AMPK inhibition in health and disease.High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects.Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene ExpressionDifferential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats.AMP-activated protein kinase signaling in metabolic regulation.AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cellsSorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.Update on the protective molecular pathways improving pancreatic beta-cell dysfunctionComparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues.Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic β-cells.Targeting the AMPK pathway for the treatment of Type 2 diabetes.Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy.AMP-activated protein kinase and metabolic control.AMP-activated protein kinase modulators: a patent review (2006 - 2010).FADD phosphorylation impaired islet morphology and function.Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.Maintenance of redox state and pancreatic beta-cell function: role of leptin and adiponectin.Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.Glucose plus metformin compared with glucose alone on β-cell function in mouse pancreatic isletsLKB1 regulates pancreatic beta cell size, polarity, and function.SNP discovery and haplotype analysis in the bovine PRKAA2 gene.
P2860
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P2860
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Metformin, but not leptin, reg ...... -stimulated insulin secretion.
@en
type
label
Metformin, but not leptin, reg ...... -stimulated insulin secretion.
@en
prefLabel
Metformin, but not leptin, reg ...... -stimulated insulin secretion.
@en
P2093
P2860
P50
P1476
Metformin, but not leptin, reg ...... -stimulated insulin secretion.
@en
P2093
Greg S Korbutt
Guy A Rutter
Ray V Rajotte
Rebecca L Rowe
Richard Smith
Wolfram W Woltersdorf
P2860
P304
P356
10.1152/AJPENDO.00532.2003
P577
2004-02-10T00:00:00Z