Novel mode of action of tylophorine analogs as antitumor compounds.
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c-Jun-mediated anticancer mechanisms of tylophorineDCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanismStudy of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer DrugNucleoplasmic calcium is required for cell proliferation.Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues.Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.Synthesis, biological evaluation and mechanism studies of deoxytylophorinine and its derivatives as potential anticancer agentsSynthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activityCryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorineAntitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotargetAntitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancerTREX1 acts in degrading damaged DNA from drug-treated tumor cells.Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis.Total synthesis of (S)-(+)-tylophorine via enantioselective intramolecular alkene carboamination.Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways.Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70Structural analogs of tylophora alkaloids may not be functional analogs.Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents.Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy.The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis.In vitro cytotoxic screening of selected Saudi medicinal plants.Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication.Induced differentiation of hepatocellular carcinoma by natural products.Total synthesis of the reported structure of 13a-hydroxytylophorine.An enantioselective strategy for the total synthesis of (S)-tylophorine via catalytic asymmetric allylation and a one-pot DMAP-promoted isocyanate formation/Lewis acid catalyzed cyclization sequence.A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis.
P2860
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P2860
Novel mode of action of tylophorine analogs as antitumor compounds.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Novel mode of action of tylophorine analogs as antitumor compounds.
@en
type
label
Novel mode of action of tylophorine analogs as antitumor compounds.
@en
prefLabel
Novel mode of action of tylophorine analogs as antitumor compounds.
@en
P2093
P1433
P1476
Novel mode of action of tylophorine analogs as antitumor compounds.
@en
P2093
Conrad Kaczmarek
David C Baker
Sanbao Zhong
Yung-Chi Cheng
P304
P356
10.1158/0008-5472.CAN-03-1904
P407
P577
2004-01-01T00:00:00Z