about
Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperatureChanges in a phospholipid bilayer induced by the hydrolysis of a phospholipase A2 enzyme: a molecular dynamics simulation study.Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves.Activated human mast cells induce LOX-1-specific scavenger receptor expression in human monocyte-derived macrophages.Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregationCarboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.Enhanced extracellular lipid accumulation in acidic environments.Lipoprotein modification by secretory phospholipase A(2) enzymes contributes to the initiation and progression of atherosclerosis.Acidification of the intimal fluid: the perfect storm for atherogenesisTailor-made approach for selective isolation and elution of low-density lipoproteins by immunoaffinity sorbent on silica.Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages.Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cellsConformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH.Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans.Sugar treatment of human lipoprotein particles and their separation by capillary electrophoresis.Open tubular capillary electrochromatography: a useful microreactor for collagen I glycation and interaction studies with low-density lipoprotein particles.Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein-steroid interactions.High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease.Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles.Myeloperoxidase and hypochlorite, but not copper ions, oxidize heparin-bound LDL particles and release them from heparin.Three complementary techniques for the clarification of temperature effect on low-density lipoprotein-chondroitin-6-sulfate interaction.Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells.Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids.In situ delipidation of low-density lipoproteins in capillary electrochromatography yields apolipoprotein B-100-coated surfaces for interaction studies.Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans.Human low-density lipoprotein-coated capillaries in electrochromatography.Decrease in pH strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans.Spatial distributions of lipids in atherosclerosis of human coronary arteries studied by time-of-flight secondary ion mass spectrometry.Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties.Phospholipase A(2)-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH.PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions.Open tubular capillary electrochromatography: a new technique for in situ enzymatic modification of low density lipoprotein particles and their protein-free derivatives.p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves.Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis.High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level.
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P50
description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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name
Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Paananen
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Paananen K
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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Katariina Öörni
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P106
P1153
6602611808
P21
P31
P496
0000-0002-9525-0250