100 years lock-and-key concept: are peptide keys shaped and guided to their receptors by the target cell membrane?
about
Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug actionBiophysical methods to study ligand-receptor interactions of neuropeptide YMolecular dynamics study of substance P peptides in a biphasic membrane mimicMolecular dynamics study of substance P peptides partitioned in a sodium dodecylsulfate micelleStructural studies by 1H NMR and molecular modeling of peptide substrates of thermolysin in relation with its proteasic activity in water and glycerol.Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers.The structure and dynamics of ACTH (1-10) on the surface of a sodium dodecylsulfate (SDS) micelle: a molecular dynamics simulation study.Probing conformational disorder in neurotensin by two-dimensional solid-state NMR and comparison to molecular dynamics simulationsThe lipid-associated 3D structure of SPA, a broad-spectrum neuropeptide antagonist with anticancer properties.NMR conformational studies of micelle-bound orexin-B: a neuropeptide involved in the sleep/awake cycle and feeding regulation.Solution structure of nociceptin peptides.Are hormones from the neuropeptide Y family recognized by their receptors from the membrane-bound state?Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices.Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs.The spin label amino acid TOAC and its uses in studies of peptides: chemical, physicochemical, spectroscopic, and conformational aspects.Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time.How sterol tilt regulates properties and organization of lipid membranes and membrane insertions.On the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action.Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivoInfluence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates.Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterolThe micelle-associated 3D structures of Boc-Y(SO3)-Nle-G-W-Nle-D-2-phenylethylester (JMV-180) and CCK-8(s) share conformational elements of a calculated CCK1 receptor-bound model.Specific membrane binding of neurotoxin II can facilitate its delivery to acetylcholine receptorEffects of the incorporation of CHAPS into SDS micelles on neuropeptide-micelle binding: separation of the role of electrostatic interactions from hydrophobic interactions.Correlation of secondary structures of bradykinin B1 receptor antagonists with their activity.Molecular dynamics simulations of adrenocorticotropin (1-24) peptide in a solvated dodecylphosphocholine (DPC) micelle and in a dimyistoylphosphatidylcholine (DMPC) bilayer.Electron paramagnetic resonance backbone dynamics studies on spin-labelled neuropeptide Y analogues.The NMR-derived conformation of orexin-A: an orphan G-protein coupled receptor agonist involved in appetite regulation and sleep.NMR conformational analyses on (des-bromo) neuropeptide B [1-23] and neuropeptide W [1-23]: the importance of alpha-helices, a cation-pi interaction and a beta-turn.Polypharmacy through Phage Display: Selection of Glucagon and GLP-1 Receptor Co-agonists from a Phage-Displayed Peptide Library.Mapping of ligand binding sites of the cholecystokinin-B/gastrin receptor with lipo-gastrin peptides and molecular modeling.Characterization of substance P-membrane interaction by transferred nuclear Overhauser effect.On the bioactive conformation of a small peptide and its set of thermodynamically accessible conformations.Link between a high for drug binding and a fast clinical action: to be or not to be?
P2860
Q24595639-B1E0931A-4C46-4A35-A866-41259B1AADF3Q28220437-72981D6A-1C37-41E8-A032-5C803879914FQ30558884-337AC5B8-00E1-4357-ADC2-E03FCD9486FFQ30558886-8C0DFC5F-708C-4790-9DBC-ABC8446D3788Q30577396-22A6A500-2996-4908-8C61-4FE2EC567EA8Q30618753-F231D161-2795-4F6A-A059-75D0DBC95B91Q30624339-87BED330-5712-48C3-8F93-6F3A5709D74AQ30993418-570CE81A-30F1-414C-A675-10389C2D35E6Q31062057-2A14FCE3-644E-4C7A-A45B-ED0E9779853DQ33194998-66AA2F47-B276-40D4-A2C9-46026E2DDC09Q34952116-709ACA78-272B-461C-A5DB-A966F3AC668AQ36204247-A093AB2D-E6CB-4BB5-B22D-B05C5ADB4AFEQ37232161-173ADF7D-1BC1-420E-888A-3325D5D52D22Q37834512-B28455A5-9655-49AC-BF52-0C5AD93AA8BEQ37986052-FD2C8831-4FAE-4CFE-A69C-6D607C181791Q38028657-8A6D3DD9-A951-4B6F-8C8A-08E1B7A3B832Q38071840-CA750B0A-8996-4C21-8E02-737A7DCF31B7Q38545579-B7E40F52-663D-4773-8048-2D7A85909DB5Q38822818-E2DA0F31-09AC-4BDB-9417-35DE150FCDC1Q39002295-6B0A815D-5DB5-492A-8BE2-9F1DC969993BQ39826205-969F5C92-29A9-46A4-895B-5D0E63F884A0Q41906066-F3936660-CCA4-48DA-A2C5-0A4B5A6BF388Q42146587-81E79C9C-49E0-42FC-BBCD-B745BDA30820Q43564197-134CE1E0-EF0A-4320-B6B3-4C7FF4298F69Q43885472-A17E1547-0FF6-4506-9D68-C4880C4E2F5EQ44080472-F4FB3061-B915-4520-A7C9-02EC1884288AQ44275356-FF69787A-1B3B-4EA7-89B2-9D41736D6CD9Q44574021-9E192BCF-F102-4F57-AE65-F012EA17A716Q46511948-861B133A-4EAD-4067-B5A1-3F4D50C23AE8Q48251736-5C24E796-22D0-4AC5-9C04-BDA926689177Q50182865-DCB16A95-E823-459F-B7EC-460F29813C85Q52075495-572AC74E-4C28-47CD-B6BA-009B441E81DAQ52295159-DDB9E37D-AF75-4489-9B9B-D6421B041341Q57133316-421CA64E-74F6-4F81-8CB5-6502A0E4154B
P2860
100 years lock-and-key concept: are peptide keys shaped and guided to their receptors by the target cell membrane?
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
100 years lock-and-key concept ...... s by the target cell membrane?
@en
type
label
100 years lock-and-key concept ...... s by the target cell membrane?
@en
prefLabel
100 years lock-and-key concept ...... s by the target cell membrane?
@en
P356
P1433
P1476
100 years lock-and-key concept ...... s by the target cell membrane?
@en
P2093
Schwyzer R
P356
10.1002/BIP.360370104
P577
1995-01-01T00:00:00Z