The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.
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Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytesNotch1 regulates the fate of cardiac progenitor cellsSignaling Pathways and Gene Regulatory Networks in Cardiomyocyte DifferentiationCongenital heart disease-causing Gata4 mutation displays functional deficits in vivoMorphogenesis of the right ventricle requires myocardial expression of Gata4Baf60c is essential for function of BAF chromatin remodelling complexes in heart developmentSertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic heartsBuilding the mammalian heart from two sources of myocardial cellsGenetic networks governing heart development.RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression.Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes.Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression.Myocardin regulates BMP10 expression and is required for heart development.PIAS1 is a GATA4 SUMO ligase that regulates GATA4-dependent intestinal promoters independent of SUMO ligase activity and GATA4 sumoylation.Prediction and validation of protein-protein interactors from genome-wide DNA-binding data using a knowledge-based machine-learning approachMulan: multiple-sequence local alignment and visualization for studying function and evolution.Heart failure and pulmonary hypertension.Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modulesInefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5Examining the cardiac NK-2 genes in early heart development.BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH.Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cellsPeptidomimetic small-molecule compounds promoting cardiogenesis of stem cells.Phosphorylation of Shox2 is required for its function to control sinoatrial node formation.Re-employment of developmental transcription factors in adult heart diseaseGATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5.GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesisDifferentiation pathways in human embryonic stem cell-derived cardiomyocytes.Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.Early cardiac development: a view from stem cells to embryosRole of the GATA family of transcription factors in endocrine development, function, and diseaseEvolutionary conservation of Nkx2.5 autoregulation in the second heart field.NADPH oxidase 4 regulates cardiomyocyte differentiation via redox activation of c-Jun protein and the cis-regulation of GATA-4 gene transcriptionCardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis.Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation.Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis.Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.
P2860
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P2860
The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The cardiac determination fact ...... via a novel upstream enhancer.
@en
type
label
The cardiac determination fact ...... via a novel upstream enhancer.
@en
prefLabel
The cardiac determination fact ...... via a novel upstream enhancer.
@en
P2093
P2860
P356
P1476
The cardiac determination fact ...... via a novel upstream enhancer.
@en
P2093
Carl O Brown
Eduardo Garcia-Gras
Manabu Shirai
Robert J Schwartz
Xin-Hua Feng
P2860
P304
10659-10669
P356
10.1074/JBC.M301648200
P407
P577
2003-12-08T00:00:00Z