Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase.
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Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell linesEGFR ligands exhibit functional differences in models of paracrine and autocrine signalingDesign, synthesis, and docking studies of peptidomimetics based on HER2-herceptin binding site with potential antiproliferative activity against breast cancer cell lines.A conformationally constrained peptidomimetic binds to the extracellular region of HER2 proteinTNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells.Structure-activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines.ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer.EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate.Functional selectivity of EGF family peptide growth factors: implications for cancer.The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.Epiregulin: roles in normal physiology and cancerThe antibody sc-33040-R fails to specifically recognize phosphorylation of ErbB4 on tyrosine1056Inter-conversion of neuregulin2 full and partial agonists for ErbB4.Negative constraints underlie the ErbB specificity of epidermal growth factor-like ligands.The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.Phe45 of NRG2beta is critical for the affinity of NRG2beta for ErbB4 and for potent stimulation of ErbB4 signaling by NRG2beta*.Ligand-based receptor tyrosine kinase partial agonists: New paradigm for cancer drug discovery?
P2860
Q24318725-D537080B-E7AE-4EAF-B7E2-E002DCBEBE3DQ26864769-AE816BE0-2318-4BB3-AB47-7FE38C54B860Q33835904-9F14FF07-313E-4FB9-9B61-729DFF8967A6Q34422576-1F3B3FD7-FCFD-4D51-8174-272651E6E6A2Q35159634-7C523878-169D-478F-8ECC-EB64F0C34848Q35185574-C2C46CC4-D23E-4BC0-A8CA-334F9882D7DEQ35755192-CF702EE5-0CE5-4EA9-90C0-F3B0DC3B481EQ36426553-4AAECECC-BD64-4CF5-8552-990BC6E1382DQ37149729-92D5B60B-E9CB-48A3-859F-0A2A8CD45D06Q37650953-63C6FE03-A3EB-4166-BE32-E908A843D3F8Q38196137-A892D6DA-DD56-4D6B-9C1A-2CD36E05A940Q39406282-D6346D40-A356-4CDF-85FB-696024C62B85Q40065960-B5B5A891-7695-491E-8AD6-0508C89C1474Q40221662-E4881209-1A80-40BE-962C-6A63441CFE7DQ40323538-AC2C9CD4-F9BA-4F4B-AE57-4EEEF3EF8558Q40341840-EB8C62BB-D002-4B57-90BC-7C2495266D95Q42050622-6F936F28-213F-46FE-8C59-B449DEBDB170
P2860
Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Five carboxyl-terminal residue ...... rbB4 receptor tyrosine kinase.
@en
type
label
Five carboxyl-terminal residue ...... rbB4 receptor tyrosine kinase.
@en
prefLabel
Five carboxyl-terminal residue ...... rbB4 receptor tyrosine kinase.
@en
P2093
P2860
P356
P1433
P1476
Five carboxyl-terminal residue ...... rbB4 receptor tyrosine kinase.
@en
P2093
Ann T D Le
David J Riese
Elizabeth M Cameron
Erika N Blommel
Richard M Gallo
Robert P Hammer
Stephanie L Coffing
Stuart S Hobbs
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207250
P407
P577
2004-01-01T00:00:00Z
P5875
P6179
1012040669