Phosphorylation of tyrosine 393 in the kinase domain of Bcr-Abl influences the sensitivity towards imatinib in vivo.
about
A Src-like inactive conformation in the abl tyrosine kinase domainAssociation between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatmentLyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib.Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.
P2860
Q28469170-D6B5A90C-582B-411B-8692-66256E6193C2Q33988398-B58842B8-5873-4E63-A3C9-0F8CB7276589Q35071103-D665D618-7BC4-436D-92AE-F8FE79DC1406Q35663526-25E2EEDE-FFFB-4B7D-9280-60614D91C483Q36508969-F53BCE0C-5173-4E97-908F-BB20749EF0E4Q42805035-24E8B366-E68D-429B-99DB-3838FE6E6F2FQ46758728-11C933C3-1C0A-4634-B925-3A9D69FC04D0
P2860
Phosphorylation of tyrosine 393 in the kinase domain of Bcr-Abl influences the sensitivity towards imatinib in vivo.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Phosphorylation of tyrosine 39 ...... vity towards imatinib in vivo.
@en
type
label
Phosphorylation of tyrosine 39 ...... vity towards imatinib in vivo.
@en
prefLabel
Phosphorylation of tyrosine 39 ...... vity towards imatinib in vivo.
@en
P2093
P2860
P356
P1433
P1476
Phosphorylation of tyrosine 39 ...... ivity towards imatinib in vivo
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.LEU.2403040
P577
2003-09-01T00:00:00Z
P5875
P6179
1015210130