The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors.
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International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease statesGastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systemsPotential Clinical Implications of the Urotensin II Receptor Antagonists.Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the βγ subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein kinase C β1 isoform.Discovery of new antagonists aimed at discriminating UII and URP-mediated biological activities: insight into UII and URP receptor activation.Therapeutic targets in hypertension: is there a place for antagonists of the most potent vasoconstrictors?Urotensin-II Ligands: An Overview from Peptide to Nonpeptide StructuresNonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375.Update on the urotensinergic system: new trends in receptor localization, activation, and drug designUrantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.Urotensin II inhibits carotid sinus baroreflex in anesthetized male rats.
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P2860
The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The neuromedin B receptor anta ...... nd rat urotensin-II receptors.
@en
type
label
The neuromedin B receptor anta ...... nd rat urotensin-II receptors.
@en
prefLabel
The neuromedin B receptor anta ...... nd rat urotensin-II receptors.
@en
P2093
P2860
P356
P1476
The neuromedin B receptor anta ...... nd rat urotensin-II receptors.
@en
P2093
Christopher L Herold
David J Behm
Henry M Sarau
James J Foley
Peter T Buckley
Stephen A Douglas
William E Wixted
P2860
P304
P356
10.1038/SJ.BJP.0705251
P407
P577
2003-05-01T00:00:00Z