Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis. - Wikidata - awgldk - TriplyDB

Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

http://www.wikidata.org/entity/Q40646969

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Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin Targeting caspases in cancer therapeutics Modeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug design Creation of an apoptin-derived peptide that interacts with SH3 domains and inhibits glioma cell migration and invasion.Mapping of apoptin-interaction with BCR-ABL1, and development of apoptin-based targeted therapy.Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.A novel anti-CD22 scFv-apoptin fusion protein induces apoptosis in malignant B-cells.A peptide derived from apoptin inhibits glioma growth.Apoptin enhances the oncolytic properties of vaccinia virus and modifies mechanisms of tumor regression.λ Phage nanobioparticle expressing apoptin efficiently suppress human breast carcinoma tumor growth in vivo.Enhanced tumour cell nuclear targeting in a tumour progression model.Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice.The Porcine Circovirus Type 2 Nonstructural Protein ORF3 Induces Apoptosis in Porcine Peripheral Blood Mononuclear Cells.Synthetic pH-Responsive Polymers for Protein Transduction Apoptin: specific killer of tumor cells?Secretory Transactivating Transcription-apoptin fusion protein induces apoptosis in hepatocellular carcinoma HepG2 cells.Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication Novel characteristics of the avian gyrovirus 2 genome.C-terminal region of apoptin affects chicken anemia virus replication and virulence.Naturally occurring, tumor-specific, therapeutic proteins.Mechanisms of Apoptin-induced cell death.Viral genes as oncolytic agents for cancer therapy.The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.Apoptin as a potential viral gene oncotherapeutic agent.DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin.Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.Selective apoptosis induction in MCF-7 cell line by truncated minimal functional region of Apoptin.Advances in Anticancer Protein Delivery Using Micro-/ Nanoparticles.Molecularly modified VP3 (30-121) induces apoptosis in human bladder cancer (EJ) cells but not in normal (3T3) cells.Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.Apoptin protein multimers form distinct higher-order nucleoprotein complexes with DNA.Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen.Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death.Additive cytotoxic effect of apoptin and chemotherapeutic agents paclitaxel and etoposide on human tumour cells.Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.A truncated apoptin protein variant selectively kills cancer cells.Inhibitory effect of genetically engineered mesenchymal stem cells with Apoptin on hepatoma cells in vitro and in vivo.Relevance of apoptin's integrity for its functional behavior.A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.

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P2860

Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

http://www.wikidata.org/entity/Q40646969

description

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2003年論文

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2003年论文

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2003年论文

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name

Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

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type

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Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

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Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

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Journal of Biological Chemistry

P1476

Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.

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Arend Van Zon

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Astrid A A M Danen-Van Oorschot

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Dominik Mumberg

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Jan-Pieter Abrahams

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Marian W Bolk

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Mathieu H M Noteborn

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Maud C M J Seelen

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S Rutger Leliveld

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Stefan J Erkeland

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Ying-Hui Zhang

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P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1

Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

Nuclear targeting sequences--a consensus?

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

Nucleocytoplasmic transport: the soluble phase

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

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27729-27736

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10.1074/JBC.M303114200

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30

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278

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Mathieu H. M. Noteborn

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