Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes.
about
Exploring steric constraints on protein mutations using MAGE/PROBEThe effect of mutations surrounding and within the active site on the catalytic activity of ricin A chainPokeweed antiviral protein: its cytotoxicity mechanism and applications in plant disease resistanceIdentification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screenIsolation and characterization of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: identification of residues important for toxicityCloning and expression of three abrin A-chains and their mutants derived by site-specific mutagenesis in Escherichia coli.Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae.Dislocation of ricin toxin A chains in human cells utilizes selective cellular factorsAB toxins: a paradigm switch from deadly to desirableWild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiaeInvestigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesis.Analysis of the contribution of an amphiphilic alpha-helix to the structure and to the function of ricin A chain.A computational perspective of molecular interactions through virtual screening, pharmacokinetic and dynamic prediction on ribosome toxin A chain and inhibitors of Ricinus communis.Minimum domain of the Shiga toxin A subunit required for enzymatic activity.Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunits.N-glycosylation does not affect the catalytic activity of ricin a chain but stimulates cytotoxicity by promoting its transport out of the endoplasmic reticulum.Targeting ricin to the ribosome.An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swineMapping the minimal contiguous gene segment that encodes functionally active Shiga-like toxin IIDetermination by systematic deletion of the amino acids essential for catalysis by ricin A chain.Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalkConserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome.Generation of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: evidence that ribosome depurination is not sufficient for cytotoxicity.Modeling of the three-dimensional structure of luffin-alpha and its simulated reaction with the substrate oligoribonucleotide GAGA.Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomesImproved stability of a protein vaccine through elimination of a partially unfolded stateStructure/function relationship study of Gln156, Glu160 and Glu189 in the active site of trichosanthin.
P2860
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P2860
Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Role of glutamic acid 177 of t ...... tic inactivation of ribosomes.
@en
type
label
Role of glutamic acid 177 of t ...... tic inactivation of ribosomes.
@en
prefLabel
Role of glutamic acid 177 of t ...... tic inactivation of ribosomes.
@en
P2093
P2860
P356
P1476
Role of glutamic acid 177 of t ...... tic inactivation of ribosomes.
@en
P2093
P2860
P304
P356
10.1128/MCB.9.11.5012
P407
P577
1989-11-01T00:00:00Z