The role of presenilin cofactors in the gamma-secretase complex.
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinFerritin light chain interacts with PEN-2 and affects γ-secretase activityAATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitorTransmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complexAnalysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERMNovel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolismDecreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretaseCD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide productionSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.The potential role of amyloid beta in the pathogenesis of age-related macular degeneration.Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrinElectron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's diseasePathways towards and away from Alzheimer's diseaseWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseNSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoIntracellular Calcium Dysregulation: Implications for Alzheimer's DiseaseUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesTrafficking regulation of proteins in Alzheimer's diseaseγ-Secretase inhibitors and modulators.Caenorhabditis elegans as a model organism to study APP functionTargeting γ-secretase in breast cancerToward the structure of presenilin/γ-secretase and presenilin homologsGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseAxonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cellsThree-dimensional structure of human γ-secretaseAPP processing in Alzheimer's diseaseComplex regulation of γ-secretase: from obligatory to modulatory subunitsAn atomic structure of human γ-secretaseA conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complexThe ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generationCoordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivationProteolytic processing of Alzheimer's β-amyloid precursor proteinPresenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activityA nine-transmembrane domain topology for presenilin 1Assembly, trafficking and function of gamma-secretasePen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1
P2860
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P2860
The role of presenilin cofactors in the gamma-secretase complex.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The role of presenilin cofactors in the gamma-secretase complex.
@en
type
label
The role of presenilin cofactors in the gamma-secretase complex.
@en
prefLabel
The role of presenilin cofactors in the gamma-secretase complex.
@en
P2093
P921
P356
P1433
P1476
The role of presenilin cofactors in the gamma-secretase complex.
@en
P2093
Gopal Thinakaran
Ikuo Hayashi
Makiko Tsuruoka
Manabu Niimura
Nobumasa Takasugi
Takeshi Iwatsubo
Yasuko Takahashi
P2888
P304
P356
10.1038/NATURE01506
P407
P577
2003-03-16T00:00:00Z
P6179
1030517937